Synthesis, Anti-Inflammatory, and Analgesic Evaluation of Some 2-Amino-5-Selenothiazoles

被引：29
作者：
Gouda, Moustafa A. [1 ,2 ]
Sherif, Yousery El-Sayed [2 ,3 ]
Elsherbini, Mohamed S. [4 ]
机构：
[1] Mansoura Univ, Fac Sci, Dept Chem, Mansoura 35516, Egypt
[2] Taibah Univ, Fac Sci & Arts, Dept Chem, Ulla, Saudi Arabia
[3] Mansoura Univ, Dept Clin Pharmacol, Fac Med, Mansoura 35516, Egypt
[4] Al Jouf Univ, Dept Chem, Fac Sci, Sakaka, Saudi Arabia
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2014年 / 189卷 / 11期
关键词：
coumarin; analgesic agent; naphthoquinone; anti-inflammatory; 2-Amino-thiazole; triselenium dicyanide; DERIVATIVES; AGENTS; ARTHRITIS; ADJUVANT; RATS; ANTICANCER; INHIBITORS; THIAZOLES; INJECTION; DESIGN;
D O I：
10.1080/10426507.2014.884091
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Treatment of 2-aminothiazole (1) with triselenium dicyanide (2) afforded selenocyanate (3). Reduction of 3 with NaBH4 gave the diselenide 4. Compounds 3 and 4 were used as a key intermediate for the synthesis of a series of 2-amino-5-selenothiazoles. The newly synthesized compounds were evaluated as anti-inflammatory and analgesic agent.
引用
收藏
页码：1633 / 1643
页数：11
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