Synthesis, Anti-Inflammatory, and Analgesic Evaluation of Some 2-Amino-5-Selenothiazoles

被引：29

作者：

Gouda, Moustafa A. ^{[1
,2
]}

Sherif, Yousery El-Sayed ^{[2
,3
]}

Elsherbini, Mohamed S. ^{[4
]}

机构：

[1] Mansoura Univ, Fac Sci, Dept Chem, Mansoura 35516, Egypt

[2] Taibah Univ, Fac Sci & Arts, Dept Chem, Ulla, Saudi Arabia

[3] Mansoura Univ, Dept Clin Pharmacol, Fac Med, Mansoura 35516, Egypt

[4] Al Jouf Univ, Dept Chem, Fac Sci, Sakaka, Saudi Arabia

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2014年 / 189卷 / 11期

关键词：

coumarin; analgesic agent; naphthoquinone; anti-inflammatory; 2-Amino-thiazole; triselenium dicyanide; DERIVATIVES; AGENTS; ARTHRITIS; ADJUVANT; RATS; ANTICANCER; INHIBITORS; THIAZOLES; INJECTION; DESIGN;

D O I：

10.1080/10426507.2014.884091

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Treatment of 2-aminothiazole (1) with triselenium dicyanide (2) afforded selenocyanate (3). Reduction of 3 with NaBH4 gave the diselenide 4. Compounds 3 and 4 were used as a key intermediate for the synthesis of a series of 2-amino-5-selenothiazoles. The newly synthesized compounds were evaluated as anti-inflammatory and analgesic agent.

引用

页码：1633 / 1643

页数：11

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