Daratumumab for Delayed Red-Cell Engraftment after Allogeneic Transplantation

被引：76

作者：

Chapuy, Claudia I. ^{[1
,5
]}

Kaufman, Richard M. ^{[2
]}

Alyea, Edwin P. ^{[4
]}

Connors, Jean M. ^{[3
]}

机构：

[1] St Elizabeths Med Ctr, Dana Farber Canc Inst, Boston, MA USA

[2] Brigham & Womens Hosp, Dept Pathol, Blood Bank, 75 Francis St, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Div Hematol, 75 Francis St, Boston, MA 02115 USA

[4] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[5] Univ Med Ctr, Dept Hematol & Oncol, Gottingen, Germany

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2018年 / 379卷 / 19期

关键词：

BONE-MARROW-TRANSPLANTATION; VERSUS-HOST-DISEASE; PERIPHERAL-BLOOD; MULTIPLE-MYELOMA; HPC TRANSPLANTATION; APLASIA; RITUXIMAB; ERYTHROPOIETIN; MONOTHERAPY; ANTIBODY;

D O I：

10.1056/NEJMoa1807438

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Daratumumab, a human IgG1 monoclonal antibody targeting CD38, is used to treat multiple myeloma. We describe successful treatment with daratumumab in a case of treatment-refractory pure red-cell aplasia after ABO-mismatched allogeneic stem-cell transplantation. The patient was a 72-year-old man with the myelodysplastic syndrome who received a transplant from an HLA-matched, unrelated donor with a major ABO incompatibility (blood group A in the donor and blood group O in the recipient). The patient had persistent circulating anti-A antibodies and no red-cell recovery 200 days after transplantation. Standard treatments had no effect. Within 1 week after the initiation of treatment with daratumumab, he no longer required transfusions.

引用

页码：1846 / 1850

页数：5

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