Potassium organotrifluoroborates: New perspectives in organic synthesis

A reagent called potassium organotrifluoroborates in organic synthesis has been reviewed as a promising alternative to organoboronic acids. Preparation of these reagents can be done using potassium hydrogen difluoride, isolated boronic acids, via transmetalation reactions, and/ or hydroboration C-H bond activation. There is an increased interest in these boron ate complexes due to the exceptional stability toward oxygen and moisture as compared to all other described organoboron derivatives. Other benefits include ease of preparation and purification with higher yields, can easily be functionalized using a great variety of reactions, high solubility in polar solvents, purity of salts can easily be checked by nuclear magnetic resonance, and shows comparable and superior reactivity compared to organoboronic acids.