Association of DNA repair gene polymorphisms with colorectal cancer risk and treatment outcomes

被引：15

作者：

Al-Shaheri, Fawaz N. ^{[1
,2
,3
]}

Al-Shami, Kamal M. ^{[4
,7
]}

Gamal, Eshrak H. ^{[3
,5
]}

Mahasneh, Amjad A. ^{[6
]}

Ayoub, Nehad M. ^{[7
]}

机构：

[1] German Canc Res Ctr, Div Funct Genome Anal, Neuenheimer Feld 580, D-69120 Heidelberg, Germany

[2] Heidelberg Univ, Med Fac Heidelberg, Neuenheimer Feld 672, D-69120 Heidelberg, Germany

[3] Jordan Univ Sci & Technol, Fac Appl Med Sci, Dept Med Lab Sci, Irbid, Jordan

[4] Auburn Univ, Harrison Sch Pharm, Dept Drug Discovery & Dev, 720 South Donahue Dr, Auburn, AL 36849 USA

[5] Univ Bonn, Dept Oncol, Coll Med, Bonn, Germany

[6] Jordan Univ Sci & Technol, Fac Sci & Arts, Dept Appl Biol Sci, Irbid 22110, Jordan

[7] Jordan Univ Sci & Technol, Fac Pharm, Dept Clin Pharm, Irbid 22110, Jordan

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2020年 / 113卷

关键词：

Colorectal cancer; DNA repair; Polymorphism; Chemotherapy; SINGLE-NUCLEOTIDE POLYMORPHISMS; III COLON-CANCER; MOLECULAR PATHOLOGICAL EPIDEMIOLOGY; LIFE-STYLE FACTORS; OXALIPLATIN-BASED CHEMOTHERAPY; CELL LUNG-CANCER; MISMATCH REPAIR; MICROSATELLITE INSTABILITY; CIGARETTE-SMOKING; COMBINATION CHEMOTHERAPY;

D O I：

10.1016/j.yexmp.2019.104364

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Colorectal cancer (CRC) is the third most common carcinoma worldwide. Despite the progress in screening and treatment, CRC remains a leading cause of cancer-related mortality. Alterations to normal nucleic acid processing may drive neoplastic transformation of colorectal epithelium. DNA repair machinery performs an essential function in the protection of genome by reducing the number of genetic polymorphisms/variations that may drive carcinogenicity. Four essential DNA repair systems are known which include nucleotide excision repair (NER), base excision repair (BER), mismatch repair (MMR), and double-strand break repair (DSBR). Polymorphisms of DNA repair genes have been shown to influence the risk of cancer development as well as outcomes of treatment. Several studies demonstrated the association between genetic polymorphism of DNA repair genes and increased risk of CRC in different populations. In this review, we have summarized the impact of DNA repair gene polymorphisms on risk of CRC development and treatment outcomes. Advancements of the current understanding for the impact of DNA repair gene polymorphisms on the risk and treatment of CRC may support diagnostic and predictive roles in patients with CRC.

引用

页数：13

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