Targeting the interleukin-17 immune axis for cancer immunotherapy

被引：127

作者：

Vitiello, Gerardo A. ^{[1
]}

Miller, George ^{[1
]}

机构：

[1] NYU, Dept Surg, S Arthur Localio Lab, Sch Med, New York, NY 10016 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2020年 / 217卷 / 01期

基金：

美国国家卫生研究院;

关键词：

DELTA-T-CELLS; TUMOR MICROENVIRONMENT; TH17; CELLS; IFN-GAMMA; PROGNOSTIC MARKER; INTERFERON-GAMMA; FAMILY-MEMBERS; IL-17; EXPRESSION; CARCINOMA;

D O I：

10.1084/jem.20190456

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of IL-17 in cancer remains controversial. Emerging evidence suggests that during early oncogenesis IL-17 supports tumor growth, whereas in established tumors IL-17 production by gamma delta and Th17 cells potentiates antitumor immunity. Consequently, gamma delta and Th17 cells are attractive targets for immunotherapy in the IL-17 immune axis. To optimize IL-17-based immunotherapy, a deeper understanding of the cytokines dictating IL-17 production and the polarity of gamma delta and Th17 cells is critical. Here, we delve into the dichotomous roles of IL-17 in cancer and provide insight into the tumor microenvironment conducive for successful IL-17-based gamma delta and Th17 cell immunotherapy.

引用

页数：11

共 126 条

[21] Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy [J].

Chowell, Diego ;

Morris, Luc G. T. ;

Grigg, Claud M. ;

Weber, Jeffrey K. ;

Samstein, Robert M. ;

Makarov, Vladimir ;

Kuo, Fengshen ;

Kendall, Sviatoslav M. ;

Requena, David ;

Riaz, Nadeem ;

Greenbaum, Benjamin ;

Carroll, James ;

Garon, Edward ;

Hyman, David M. ;

Zehir, Ahmet ;

Solit, David ;

Berger, Michael ;

Zhou, Ruhong ;

Rizvi, Naiyer A. ;

Chan, Timothy A. .

SCIENCE, 2018, 359 (6375) :582-+

[22] IL-17A is produced by breast cancer TILs and promotes chemoresistance and proliferation through ERK1/2 [J].

Cochaud, Stephanie ;

Giustiniani, Jerome ;

Thomas, Clemence ;

Laprevotte, Emilie ;

Garbar, Christian ;

Savoye, Aude-Marie ;

Cure, Herve ;

Mascaux, Corinne ;

Alberici, Gilles ;

Bonnefoy, Nathalie ;

Eliaou, Jean-Francois ;

Bensussan, Armand ;

Bastid, Jeremy .

SCIENTIFIC REPORTS, 2013, 3

[23] IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis [J].

Coffelt, Seth B. ;

Kersten, Kelly ;

Doornebal, Chris W. ;

Weiden, Jorieke ;

Vrijland, Kim ;

Hau, Cheei-Sing ;

Verstegen, Niels J. M. ;

Ciampricotti, Metamia ;

Hawinkels, Lukas J. A. C. ;

Jonkers, Jos ;

de Visser, Karin E. .

NATURE, 2015, 522 (7556) :345-+

[24] Differential Responsiveness of Innate-like IL-17-and IFN-β-Producing γδ T Cells to Homeostatic Cytokines [J].

Corpuz, Theresa M. ;

Stolp, Jessica ;

Kim, Hee-Ok ;

Pinget, Gabriela V. ;

Gray, Daniel H. D. ;

Cho, Jae-Ho ;

Sprent, Jonathan ;

Webster, Kylie E. .

JOURNAL OF IMMUNOLOGY, 2016, 196 (02) :645-654

[25] Cancer Immunotherapy [J].

Couzin-Frankel, Jennifer .

SCIENCE, 2013, 342 (6165) :1432-1433

[26] IL-17A in the tumor microenvironment of the human colorectal adenoma-carcinoma sequence [J].

Cui, Guanglin ;

Yuan, Aping ;

Goll, Rasmus ;

Florholmen, Jon .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2012, 47 (11) :1304-1312

[27] γδ-T cells expressing NK receptors predominate over NK cells and conventional T cells in the innate IFN-γ response to Plasmodium falciparum malaria [J].

D'Ombrain, Marthe C. ;

Hansen, Diana S. ;

Simpson, Ken M. ;

Schofield, Louis .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2007, 37 (07) :1864-1873

[28] Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance [J].

Daley, Donnele ;

Mani, Vishnu R. ;

Mohan, Navyatha ;

Akkad, Neha ;

Ochi, Atsuo ;

Heindel, Daniel W. ;

Lee, Ki Buom ;

Zambirinis, Constantinos P. ;

Pandian, Gautam S. D. Balasubramania ;

Savadkar, Shivraj ;

Torres-Hernandez, Alejandro ;

Nayak, Shruti ;

Wang, Ding ;

Hundeyin, Mautin ;

Diskin, Brian ;

Aykut, Berk ;

Werba, Gregor ;

Barilla, Rocky M. ;

Rodriguez, Robert ;

Chang, Steven ;

Gardner, Lawrence ;

Mahal, Lara K. ;

Ueberheide, Beatrix ;

Miller, George .

NATURE MEDICINE, 2017, 23 (05) :556-+

[29] γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation [J].

Daley, Donnele ;

Zambirinis, Constantinos Pantelis ;

Seifert, Lena ;

Akkad, Neha ;

Mohan, Navyatha ;

Werba, Gregor ;

Barilla, Rocky ;

Torres-Hernandez, Alejandro ;

Hundeyin, Mautin ;

Mani, Vishnu Raj Kumar ;

Avanzi, Antonina ;

Tippens, Daniel ;

Narayanan, Rajkishen ;

Jang, Jung-Eun ;

Newman, Elliot ;

Pillarisetty, Venu Gopal ;

Dustin, Michael Loran ;

Bar-Sagi, Dafna ;

Hajdu, Cristina ;

Miller, George .

CELL, 2016, 166 (06) :1485-+

[30] Anti-metastatic potential of human Vδ1+ γδ T cells in an orthotopic mouse xenograft model of colon carcinoma [J].

Devaud, Christel ;

Rousseau, Benoit ;

Netzer, Sonia ;

Pitard, Vincent ;

Paroissin, Christian ;

Khairallah, Camille ;

Costet, Pierre ;

Moreau, Jean-Francois ;

Couillaud, Franck ;

Dechanet-Merville, Julie ;

Capone, Myriam .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2013, 62 (07) :1199-1210

← 1 2 3 4 5 6 7 8 9 10 →