Targeting the interleukin-17 immune axis for cancer immunotherapy

被引：125

作者：

Vitiello, Gerardo A. ^{[1
]}

Miller, George ^{[1
]}

机构：

[1] NYU, Dept Surg, S Arthur Localio Lab, Sch Med, New York, NY 10016 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2020年 / 217卷 / 01期

基金：

美国国家卫生研究院;

关键词：

DELTA-T-CELLS; TUMOR MICROENVIRONMENT; TH17; CELLS; IFN-GAMMA; PROGNOSTIC MARKER; INTERFERON-GAMMA; FAMILY-MEMBERS; IL-17; EXPRESSION; CARCINOMA;

D O I：

10.1084/jem.20190456

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of IL-17 in cancer remains controversial. Emerging evidence suggests that during early oncogenesis IL-17 supports tumor growth, whereas in established tumors IL-17 production by gamma delta and Th17 cells potentiates antitumor immunity. Consequently, gamma delta and Th17 cells are attractive targets for immunotherapy in the IL-17 immune axis. To optimize IL-17-based immunotherapy, a deeper understanding of the cytokines dictating IL-17 production and the polarity of gamma delta and Th17 cells is critical. Here, we delve into the dichotomous roles of IL-17 in cancer and provide insight into the tumor microenvironment conducive for successful IL-17-based gamma delta and Th17 cell immunotherapy.

引用

页数：11

共 126 条

[1] The effects of IL-17 upon human natural killer cells [J].

Al Omar, Suliman ;

Flanagan, Brian F. ;

Almehmadi, Mazen ;

Christmas, Stephen E. .

CYTOKINE, 2013, 62 (01) :123-130

[2] Distinctive expression pattern of interleukin-17 cytokine family members in colorectal cancer [J].

Al-Samadi, Ahmed ;

Moossavi, Shirin ;

Salem, Abdelhakim ;

Sotoudeh, Masoud ;

Tuovinen, Sarianna M. ;

Konttinen, Yrjo T. ;

Salo, Tuula ;

Bishehsari, Faraz .

TUMOR BIOLOGY, 2016, 37 (02) :1609-1615

[3] Isopentenyl pyrophosphate-activated CD516+ γδ T lymphocytes display potent antitumor activity toward human squamous cell carcinoma [J].

Alexander, Alan A. Z. ;

Maniar, Amudhan ;

Cummings, Jean-Saville ;

Hebbeler, Andrew M. ;

Schulze, Dan H. ;

Gastman, Brian R. ;

Pauza, C. David ;

Strome, Scott E. ;

Chapoval, Andrei I. .

CLINICAL CANCER RESEARCH, 2008, 14 (13) :4232-4240

[4] The paradox of Th17 cell functions in tumor immunity [J].

Asadzadeh, Zahra ;

Mohammadi, Hamed ;

Safarzadeh, Elham ;

Hemmatzadeh, Maryam ;

Mahdian-Shakib, Ahmad ;

Jadidi-Niaragh, Farhad ;

Azizi, Gholamreza ;

Baradaran, Behzad .

CELLULAR IMMUNOLOGY, 2017, 322 :15-25

[5] Th17 cellsin cancer: the ultimate identity crisis [J].

Bailey, Stefanie R. ;

Nelson, Michelle H. ;

Himes, Richard A. ;

Li, Zihai ;

Mehrotra, Shikhar ;

Paulos, Chrystal M. .

FRONTIERS IN IMMUNOLOGY, 2014, 5

[6] Broadening the Impact of Immunotherapy to Pancreatic Cancer: Challenges and Opportunities [J].

Balachandran, Vinod P. ;

Beatty, Gregory L. ;

Dougan, Stephanie K. .

GASTROENTEROLOGY, 2019, 156 (07) :2056-2072

[7] The Inhibitory Receptor BTLA Controls γδ T Cell Homeostasis and Inflammatory Responses [J].

Bekiaris, Vasileios ;

Sedy, John R. ;

Macauley, Matthew G. ;

Rhode-Kurnow, Antje ;

Ware, Carl F. .

IMMUNITY, 2013, 39 (06) :1082-1094

[8] Interleukin-17 inhibits tumor cell growth by means of a T-cell-dependent mechanism [J].

Benchetrit, F ;

Ciree, A ;

Vives, V ;

Warnier, G ;

Gey, A ;

Sautès-Fridman, C ;

Fossiez, F ;

Haicheur, N ;

Fridman, WH ;

Tartour, E .

BLOOD, 2002, 99 (06) :2114-2121

[9] Phase-I study of Innacell γδ™, an autologous cell-therapy product highly enriched in γ9δ2 T lymphocytes, in combination with IL-2, in patients with metastatic renal cell carcinoma [J].

Bennouna, Jaafar ;

Bompas, Emmanuelle ;

Neidhardt, Eve Marie ;

Rolland, Frederic ;

Philip, Irene ;

Galea, Celine ;

Salot, Samuel ;

Saiagh, Soraya ;

Audrain, Marie ;

Rimbert, Marie ;

Micheaux, Sylvie Lafaye-de ;

Tiollier, Jerome ;

Negrier, Sylvie .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2008, 57 (11) :1599-1609

[10] Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer [J].

Borghaei, H. ;

Paz-Ares, L. ;

Horn, L. ;

Spigel, D. R. ;

Steins, M. ;

Ready, N. E. ;

Chow, L. Q. ;

Vokes, E. E. ;

Felip, E. ;

Holgado, E. ;

Barlesi, F. ;

Kohlhaeufl, M. ;

Arrieta, O. ;

Burgio, M. A. ;

Fayette, J. ;

Lena, H. ;

Poddubskaya, E. ;

Gerber, D. E. ;

Gettinger, S. N. ;

Rudin, C. M. ;

Rizvi, N. ;

Crino, L. ;

Blumenschein, G. R. ;

Antonia, S. J. ;

Dorange, C. ;

Harbison, C. T. ;

Finckenstein, F. Graf ;

Brahmer, J. R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (17) :1627-1639

← 1 2 3 4 5 6 7 8 9 10 →