Background: Argon has shown potential as an organoprotective agent in numerous models of ischemia-reperfusion injury (IRI). The aim of this study was to evaluate the effects of argon gas during ex vivo normothermic perfusion (EVNP) in an experimental porcine model of kidney IRI. Materials and methods: After a warm ischemia time of 15 min and 17 h of static cold storage, porcine kidneys underwent 1 h of EVNP using leukocyte-depleted blood. During EVNP, kidneys were perfused with a gas composition either of 70% argon (n = 6), 70% nitrogen control (n = 6), or standard 95% oxygen (n = 6) balanced with 5% carbon dioxide. After EVNP, kidneys were reperfused with whole blood under standard conditions for 3 h to assess renal function and injury. Results: During 1-h EVNP, the mean renal blood flow was numerically higher in the argon group (49.2 +/- 16.2 mL/min/100 g; P = 0.320) compared with the nitrogen and oxygen groups (42.9 +/- 18.64 and 37.71 +/- 7.0 mL/min/100 g, respectively). Other measures of renal function and hemodynamics were not significantly different between the argon and control groups during this period. During reperfusion, no significant differences were found in functional parameters or inflammatory markers (P < 0.05). Histologic analysis revealed no significant change in morphology or hypoxia-inducible factor-1 alpha staining between gaseous groups. Nuclear hypoxia-inducible factor-1 alpha staining was observed only after 3 h of reperfusion. Conclusions: Our findings suggest that using 70% argon during 1 h of EVNP does not mediate a measurable organoprotective effect in an experimental porcine model of IRI. (C) 2017 Elsevier Inc. All rights reserved.
机构:
Univ Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Conde, Elisa
Alegre, Laura
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Inst Invest Princesa IP, Dept Nephrol, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Alegre, Laura
Blanco-Sanchez, Ignacio
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Blanco-Sanchez, Ignacio
Saenz-Morales, David
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Saenz-Morales, David
Aguado-Fraile, Elia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Aguado-Fraile, Elia
Ponte, Belen
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Ponte, Belen
Ramos, Edurne
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Ramos, Edurne
Saiz, Ana
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Saiz, Ana
Jimenez, Carlos
论文数: 0引用数: 0
h-index: 0
机构:
Hosp La Paz IdIPaz, Dept Nephrol, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Jimenez, Carlos
Ordonez, Angel
论文数: 0引用数: 0
h-index: 0
机构:
Inst Invest Princesa IP, Dept Immunol, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Ordonez, Angel
Lopez-Cabrera, Manuel
论文数: 0引用数: 0
h-index: 0
机构:
CSIC UAM, Ctr Biol Mol Severo Ochoa, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Lopez-Cabrera, Manuel
del Peso, Luis
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Madrid, Sch Med, Inst Biomed Res Alberto Sols, CSIC UAM,Dept Biochem,Hosp La Paz IdiPAZ,HIV Unit, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
del Peso, Luis
de Landazuri, Manuel O.
论文数: 0引用数: 0
h-index: 0
机构:
Inst Invest Princesa IP, Dept Immunol, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
de Landazuri, Manuel O.
Liano, Fernando
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Ramon & Cajal, Dept Nephrol, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Liano, Fernando
Selgas, Rafael
论文数: 0引用数: 0
h-index: 0
机构:
Hosp La Paz IdIPaz, Dept Nephrol, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Selgas, Rafael
Antonio Sanchez-Tomero, Jose
论文数: 0引用数: 0
h-index: 0
机构:
Inst Invest Princesa IP, Dept Nephrol, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Antonio Sanchez-Tomero, Jose
Laura Garcia-Bermejo, Maria
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
机构:
Air Liquide Sante Int Claude Delorme Res Ctr, Air Liquide Med Gases Grp, Jouy En Josas, FranceAix Marseille Univ, APHM, Dept Urol & Kidney Transplantat, Marseille, France
机构:
Univ Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Conde, Elisa
Alegre, Laura
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Inst Invest Princesa IP, Dept Nephrol, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Alegre, Laura
Blanco-Sanchez, Ignacio
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Blanco-Sanchez, Ignacio
Saenz-Morales, David
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Saenz-Morales, David
Aguado-Fraile, Elia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Aguado-Fraile, Elia
Ponte, Belen
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Ponte, Belen
Ramos, Edurne
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Ramos, Edurne
Saiz, Ana
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Saiz, Ana
Jimenez, Carlos
论文数: 0引用数: 0
h-index: 0
机构:
Hosp La Paz IdIPaz, Dept Nephrol, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Jimenez, Carlos
Ordonez, Angel
论文数: 0引用数: 0
h-index: 0
机构:
Inst Invest Princesa IP, Dept Immunol, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Ordonez, Angel
Lopez-Cabrera, Manuel
论文数: 0引用数: 0
h-index: 0
机构:
CSIC UAM, Ctr Biol Mol Severo Ochoa, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Lopez-Cabrera, Manuel
del Peso, Luis
论文数: 0引用数: 0
h-index: 0
机构:
Univ Autonoma Madrid, Sch Med, Inst Biomed Res Alberto Sols, CSIC UAM,Dept Biochem,Hosp La Paz IdiPAZ,HIV Unit, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
del Peso, Luis
de Landazuri, Manuel O.
论文数: 0引用数: 0
h-index: 0
机构:
Inst Invest Princesa IP, Dept Immunol, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
de Landazuri, Manuel O.
Liano, Fernando
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Ramon & Cajal, Dept Nephrol, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Liano, Fernando
Selgas, Rafael
论文数: 0引用数: 0
h-index: 0
机构:
Hosp La Paz IdIPaz, Dept Nephrol, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Selgas, Rafael
Antonio Sanchez-Tomero, Jose
论文数: 0引用数: 0
h-index: 0
机构:
Inst Invest Princesa IP, Dept Nephrol, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
Antonio Sanchez-Tomero, Jose
Laura Garcia-Bermejo, Maria
论文数: 0引用数: 0
h-index: 0
机构:
Univ Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, SpainUniv Alcala de Henares, Dept Syst Disorders & Canc, Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid, Spain
机构:
Air Liquide Sante Int Claude Delorme Res Ctr, Air Liquide Med Gases Grp, Jouy En Josas, FranceAix Marseille Univ, APHM, Dept Urol & Kidney Transplantat, Marseille, France