Insulin-induced vasodilation is dependent on tetrahydrobiopterin synthesis

被引:26
|
作者
Verma, S
Arikawa, E
Yao, LF
Laher, I
McNeill, JH [1 ]
机构
[1] Univ British Columbia, Fac Pharmaceut Sci, Div Pharmacol & Toxicol, Vancouver, BC V6T 1Z3, Canada
[2] Univ British Columbia, Fac Med, Dept Pharmacol & Therapeut, Vancouver, BC V6T 1Z3, Canada
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 1998年 / 47卷 / 09期
关键词
D O I
10.1016/S0026-0495(98)90273-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Insulin has been shown to elicit vasodilation through increases in nitric oxide (NO) production. To examine whether insulin may modulate the availability of tetrahydrobiopterin (BH4) (an absolute cofactor requirement for NO synthase activation), we studied the effects of insulin (150 nmol/L) on femoral arterial reactivity (to norepinephrine [NE]) in the presence and absence of 2,4-diamino-6-hydroxypyrimidine (DAHP), a specific inhibitor of BH4 production. Our data indicate that inhibition of BH4 synthesis results in an attenuation in the vasodepressor effect of insulin. One possibility is that insulin may regulate NO production by increasing cofactor (BH4) availability for activation of NO synthase. Copyright (C) 1998 by W.B. Saunders Company.
引用
收藏
页码:1037 / 1039
页数:3
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