Update in Kaposi sarcoma

被引：5
|
作者：
Noy, A
机构：
[1] Mem Sloan Kettering Canc Ctr, Div Hematol, Dept Lymphoma & Clin Immunol, New York, NY 10021 USA
[2] Cornell Univ, Weill Med Coll, Dept Med, New York, NY 10021 USA
来源：
CURRENT OPINION IN ONCOLOGY | 2003年 / 15卷 / 05期
关键词：
Kaposi sarcoma; endothelial cells; HHV-8; HIV;
D O I：
10.1097/00001622-200309000-00006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose of review. Knowledge of the pathophysiology of Kaposi sarcoma continues to expand and influence our therapeutic approaches. This review summarizes developments within the last 18 to 24 months. Recent findings. Pieces of the puzzle as they relate to viral factors-both human herpes virus 8 (HHV-8) and human immunodeficiency virus (HIV)-endothelial cells, host immune factors, and cytokines are described. Recent observations relating to highly active antiretroviral therapy (HAART) and agents under investigation that exploit the developments in pathophysiology are reviewed. Summary. Advances in Kaposi sarcoma pathophysiology are leading to new therapeutic approaches. These will undoubtedly have an impact on other viral and malignant processes as well.
引用
收藏
页码：379 / 381
页数：3
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