Spectropathology for the next generation: Quo vadis?

被引:100
作者
Byrne, Hugh J. [1 ]
Baranska, Malgorzata [2 ]
Puppels, Gerwin J. [3 ,4 ]
Stone, Nick [5 ]
Wood, Bayden [6 ,7 ]
Gough, Kathleen M. [8 ]
Lasch, Peter [9 ]
Heraud, Phil [6 ,7 ]
Sule-Suso, Josep [10 ]
Sockalingum, Ganesh D. [11 ]
机构
[1] Dublin Inst Technol, FOCAS Res Inst, Dublin 8, Ireland
[2] Jagiellonian Univ, Fac Chem, PL-30060 Krakow, Poland
[3] RiverD Int BV, NL-3029 AK Rotterdam, Netherlands
[4] Erasmus Univ, Med Ctr, Ctr Opt Diagnost & Therapy, Dept Dermatol, Rotterdam, Netherlands
[5] Univ Exeter, Coll Engn Math & Phys Sci, Sch Phys, EBiomed Spect Lab, Exeter EX4 4QL, Devon, England
[6] Monash Univ, Ctr Biospect, Clayton, Vic 3800, Australia
[7] Monash Univ, Sch Chem, Clayton, Vic 3800, Australia
[8] Univ Manitoba, Dept Chem, Winnipeg, MB R3T 2N2, Canada
[9] Robert Koch Inst, Ctr Biol Threats & Special Pathogens Prote & Spec, D-13353 Berlin, Germany
[10] Keele Univ, Inst Sci & Technol Med, Stoke On Trent ST4 7QB, Staffs, England
[11] Univ Reims, MeDIAN Biophoton & Technol Sante, UFR Pharm, F-51096 Reims, France
基金
英国工程与自然科学研究理事会; 美国国家卫生研究院;
关键词
CONFOCAL RAMAN-SPECTROSCOPY; IN-VIVO; HUMAN-PAPILLOMAVIRUS; VIBRATIONAL SPECTROSCOPY; SPECTRAL HISTOPATHOLOGY; INFRARED-SPECTROSCOPY; DIAGNOSTIC-TOOL; HUMAN SKIN; CELLS; MICROSPECTROSCOPY;
D O I
10.1039/c4an02036g
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Although the potential of vibrational spectroscopy for biomedical applications has been well demonstrated, translation into clinical practice has been relatively slow. This Editorial assesses the challenges facing the field and the potential way forward. While many technological challenges have been addressed to date, considerable effort is still required to gain acceptance of the techniques among the medical community, standardise protocols, extend to a clinically relevant scale, and ultimately assess the health economics underlying clinical deployment. National and international research networks can contribute much to technology development and standardisation. Ultimately, large-scale funding is required to engage in clinical trials and instrument development.
引用
收藏
页码:2066 / 2073
页数:8
相关论文
共 53 条
[1]   Raman spectroscopic mapping for the analysis of solar radiation induced skin damage [J].
Ali, S. M. ;
Bonnier, F. ;
Ptasinski, K. ;
Lambkin, H. ;
Flynn, K. ;
Lyng, F. M. ;
Byrne, H. J. .
ANALYST, 2013, 138 (14) :3946-3956
[2]   Raman spectroscopic analysis of human skin tissue sections ex-vivo: evaluation of the effects of tissue processing and dewaxing [J].
Ali, Syed M. ;
Bonnier, Franck ;
Tfayli, Ali ;
Lambkin, Helen ;
Flynn, Kathleen ;
McDonagh, Vincent ;
Healy, Claragh ;
Lee, T. Clive ;
Lyng, Fiona M. ;
Byrne, Hugh J. .
JOURNAL OF BIOMEDICAL OPTICS, 2013, 18 (06)
[3]  
[Anonymous], 2014, J BIOPHOTONICS PHOTO, V7, P145
[4]  
Bancroft John D., 2002, Theory and practice of histological techniques, V5th
[5]   Large scale infrared imaging of tissue micro arrays (TMAs) using a tunable Quantum Cascade Laser (QCL) based microscope [J].
Bassan, Paul ;
Weida, Miles J. ;
Rowlette, Jeremy ;
Gardner, Peter .
ANALYST, 2014, 139 (16) :3856-3859
[6]   Transmission FT-IR Chemical Imaging on Glass Substrates: Applications in Infrared Spectral Histopathology [J].
Bassan, Paul ;
Mellor, Joe ;
Shapiro, Jonathan ;
Williams, Kaye J. ;
Lisanti, Michael P. ;
Gardner, Peter .
ANALYTICAL CHEMISTRY, 2014, 86 (03) :1648-1653
[7]   Whole organ cross-section chemical imaging using label-free mega-mosaic FTIR microscopy [J].
Bassan, Paul ;
Sachdeva, Ashwin ;
Shanks, Jonathan H. ;
Brown, Mick D. ;
Clarke, Noel W. ;
Gardner, Peter .
ANALYST, 2013, 138 (23) :7066-7069
[8]   The inherent problem of transflection-mode infrared spectroscopic microscopy and the ramifications for biomedical single point and imaging applications [J].
Bassan, Paul ;
Lee, Joe ;
Sachdeva, Ashwin ;
Pissardini, Juliana ;
Dorling, Konrad M. ;
Fletcher, John S. ;
Henderson, Alex ;
Gardner, Peter .
ANALYST, 2013, 138 (01) :144-157
[9]   Resonant Mie Scattering (RMieS) correction of infrared spectra from highly scattering biological samples [J].
Bassan, Paul ;
Kohler, Achim ;
Martens, Harald ;
Lee, Joe ;
Byrne, Hugh J. ;
Dumas, Paul ;
Gazi, Ehsan ;
Brown, Michael ;
Clarke, Noel ;
Gardner, Peter .
ANALYST, 2010, 135 (02) :268-277
[10]   Resonant Mie scattering in infrared spectroscopy of biological materials - understanding the 'dispersion artefact' [J].
Bassan, Paul ;
Byrne, Hugh J. ;
Bonnier, Franck ;
Lee, Joe ;
Dumas, Paul ;
Gardner, Peter .
ANALYST, 2009, 134 (08) :1586-1593