Cutaneous adverse events associated with immune checkpoint blockade: A systematic review and meta-analysis

被引：15

作者：

Han, Yiqun ^{[1
]}

Wang, Jiayu ^{[1
]}

Xu, Binghe ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Dept Med Oncol, Natl Canc Ctr, Natl Clin Res Ctr Canc,Canc Hosp, 17 Panjiayuan Nanli, Beijing 100021, Peoples R China

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2021年 / 163卷

关键词：

Cutaneous toxicity; Immune-related adverse events; Immune checkpoint inhibitors; Meta-analysis; CELL LUNG-CANCER; PHASE-III TRIAL; DOUBLE-BLIND; OPEN-LABEL; STAGE-III; 2ND-LINE THERAPY; TUMOR RESPONSE; PEMBROLIZUMAB; IPILIMUMAB; NIVOLUMAB;

D O I：

10.1016/j.critrevonc.2021.103376

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Dermatological toxicity is the most common immune-related adverse events (irAEs) following immune checkpoint inhibitors (ICIs). A better understanding of this side effect enables early recognition, diagnosis and management in clinical practice. We did a systematic review and meta-analysis of literature published on ClinicalTrials.gov, Pubmed, Embase, and Cochrane Library to assess the differences in cutaneous irAEs among ICIs, the effect from dosage and combined treatment on the incidence, and the predictive values for prognosis. A total of 46 eligible RCTs involving 28,569 patients were included. This study indicates that cutaneous irAEs are dose-independent and agent-specific immune reactions with the highest risk observed in CTLA-4 blockade and might not a surrogate prognostic indicator.

引用

页数：7

共 50 条

[41] Cardiovascular toxicity following immune checkpoint inhibitors: A systematic review and meta-analysis [J].

Xavier, Camila Braganca ;

Holanda Lopes, Carlos Diego ;

Harada, Guilherme ;

Bariani Peres, Eduardo Dante ;

Katz, Artur ;

Jardim, Denis Leonardo .

TRANSLATIONAL ONCOLOGY, 2022, 19

[42] Immune Checkpoint Inhibitors in Malignant Pleural Mesothelioma: A Systematic Review and Meta-Analysis [J].

Gemelli, Maria ;

Cortinovis, Diego Luigi ;

Baggi, Alice ;

di Mauro, Pierluigi ;

Calza, Stefano ;

Berruti, Alfredo ;

Grisanti, Salvatore ;

Rota, Matteo .

CANCERS, 2022, 14 (24)

[43] Treatment-Related Adverse Events of Combination Immune Checkpoint Inhibitors: Systematic Review and Meta-Analysis [J].

Park, Robin ;

Lopes, Laercio ;

Cristancho, Cagney R. ;

Riano, Ivy M. ;

Saeed, Anwaar .

FRONTIERS IN ONCOLOGY, 2020, 10

[44] Association among major adverse cardiovascular events with immune checkpoint inhibitors: A systematic review and meta-analysis [J].

Li, Haixia ;

Zheng, Yanfei ;

Li, Bin ;

Zhi, Yinghao ;

Chen, Mingxian ;

Zeng, Jing ;

Jiao, Qian ;

Tao, Yuxuan ;

Liu, Xinmei ;

Shen, Zican ;

Zhang, Jiahui ;

Zhao, Weizhe ;

Chen, Dong .

JOURNAL OF INTERNAL MEDICINE, 2025, 297 (01) :36-46

[45] Prognostic relevance of immune-related adverse events in lung cancer patients undergoing immune checkpoint inhibitor therapy: a systematic review and meta-analysis [J].

Huang, Yuchen ;

Ma, Wananqi ;

Wu, Dongsheng ;

Lyu, Mengyuan ;

Zheng, Quan ;

Wang, Tengyong ;

Zhou, Jian ;

Liu, Chengwu .

TRANSLATIONAL LUNG CANCER RESEARCH, 2024, 13 (07) :1559-1584

[46] Arthralgia adverse events due to immune-checkpoint inhibitors for lung cancer patients: a systematic review and meta-analysis [J].

Zou, Defang ;

Wang, Xiaoping ;

Sun, Yamin ;

Wang, Xi ;

Lu, Chang ;

Wang, Aiyun ;

Wang, Xia ;

Yang, Yan .

FRONTIERS IN ONCOLOGY, 2023, 13

[47] Cutaneous Adverse Events Associated with Immune Checkpoint Inhibitors: A Review Article [J].

Chen, Chieh-Hsun ;

Yu, Hsin-Su ;

Yu, Sebastian .

CURRENT ONCOLOGY, 2022, 29 (04) :2871-2886

[48] Immune checkpoint inhibitor-related cutaneous adverse events [J].

He, Chunxia ;

Qu, Tao .

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 2020, 16 (05) :E149-E153

[49] Immune checkpoint inhibitor-related adverse cardiac events in patients with lung cancer: a systematic review and meta-analysis [J].

Zhang, Xiao-Tong ;

Ge, Nan ;

Xiang, Zi-Jian ;

Liu, Tao .

CANCER CELL INTERNATIONAL, 2022, 22 (01)

[50] Kidney Adverse Events Associated with Immune Checkpoint Inhibitor Therapy A Systematic Review and Bayesian Network Meta-Analysis [J].

Trisal, Shehjar R. ;

Low, Gary ;

Pathan, Faraz ;

Komala, Muralikrishna Gangadharan .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2023, 18 (07) :843-849

← 1 2 3 4 5 →