Prevalence of Enhancer of Zeste Homolog 2 in Patients with Resected Small Cell Lung Cancer

被引：9

作者：

Toyokawa, Gouji ^{[1
]}

Takada, Kazuki ^{[1
]}

Tagawa, Tetsuzo ^{[1
]}

Kinoshita, Fumihiko ^{[1
]}

Kozuma, Yuka ^{[1
]}

Matsubara, Taichi ^{[1
]}

Haratake, Naoki ^{[1
]}

Takamori, Shinkichi ^{[1
]}

Akamine, Takaki ^{[1
]}

Hirai, Fumihiko ^{[1
]}

Yamada, Yuichi ^{[2
]}

Hamamoto, Ryuji ^{[3
]}

Oda, Yoshinao ^{[2
]}

Maehara, Yoshihiko ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Sci, Fukuoka, Fukuoka, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Anat Pathol, Fukuoka, Fukuoka, Japan

[3] Natl Canc Ctr, Div Mol Modificat & Canc Biol, Tokyo, Japan

来源：

ANTICANCER RESEARCH | 2018年 / 38卷 / 06期

基金：

日本学术振兴会;

关键词：

Small cell lung cancer; enhancer of zeste homolog 2; surgery; HISTONE METHYLTRANSFERASE EZH2; PROTEIN EXPRESSION; SURGICAL RESECTION; STAGE-I; ADENOCARCINOMA; TUMORIGENESIS; MUTATIONS; CARCINOMA; THERAPY; TARGET;

D O I：

10.21873/anticanres.12649

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that is deeply involved in cancer pathogenesis. Although clinicopathological significance of EZH2 in non-small cell lung cancer has been gradually elucidated, such significance in small cell lung cancer (SCLC) has yet to be fully investigated. Patients and Methods: Forty patients with resected SCLC were analyzed for EZH2. EZH2 expression was evaluated using the Allred score (0-8) and was classified into negative (0-6) and positive (7 and 8). We evaluated the association between EZH2 and the clinicopathological characteristics and postoperative survivals. Results: Among 40 patients, 15 (37.5%) and 25 (62.5%) were classified as being negative and positive for EZH2, respectively. Fisher's exact test demonstrated no significant associations between the positivity for EZH2 and clinicopathological characteristics. No significant differences were observed in recurrence-free and overall survivals between EZH2-negative/low and EZH2-high patients. Conclusion: EZH2 was frequently observed in patients with resected SCLC, but no significant associations were found between its expression and the clinicopathological characteristics and postoperative survivals.

引用

页码：3707 / 3711

页数：5

共 25 条

[1]

Allred DC, 1998, MODERN PATHOL, V11, P155

[2] Nivolumab alone and nivolumab plus ipilimumab in recurrent small-cell lung cancer (CheckMate 032): a multicentre, open-label, phase 1/2 trial [J].

Antonia, Scott J. ;

Lopez-Martin, Jose A. ;

Bendell, Johanna ;

Ott, Patrick A. ;

Taylor, Matthew ;

Eder, Joseph Paul ;

Jaeger, Dirk ;

Pietanza, M. Catherine ;

Le, Dung T. ;

de Braud, Filippo ;

Morse, Michael A. ;

Ascierto, Paolo A. ;

Horn, Leora ;

Amin, Asim ;

Pillai, Rathi N. ;

Evans, Jeffry ;

Chau, Ian ;

Bono, Petri ;

Atmaca, Akin ;

Sharma, Padmanee ;

Harbison, Christopher T. ;

Lin, Chen-Sheng ;

Christensen, Olaf ;

Calvo, Emiliano .

LANCET ONCOLOGY, 2016, 17 (07) :883-895

[3] EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast [J].

Bachmann, IM ;

Halvorsen, OJ ;

Collett, K ;

Stefansson, IM ;

Straume, O ;

Haukaas, SA ;

Salvesen, HB ;

Otte, AP ;

Akslen, LA .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (02) :268-273

[4] EZH2 Protein Expression Associates with the Early Pathogenesis, Tumor Progression, and Prognosis of Non-Small Cell Lung Carcinoma [J].

Behrens, Carmen ;

Solis, Luisa M. ;

Lin, Heather ;

Yuan, Ping ;

Tang, Ximing ;

Kadara, Humam ;

Riquelme, Erick ;

Galindo, Hector ;

Moran, Cesar A. ;

Kalhor, Neda ;

Swisher, Stephen G. ;

Simon, George R. ;

Stewart, David J. ;

Lee, J. Jack ;

Wistuba, Ignacio I. .

CLINICAL CANCER RESEARCH, 2013, 19 (23) :6556-6565

[5] Proteomic Profiling Identifies Dysregulated Pathways in Small Cell Lung Cancer and Novel Therapeutic Targets Including PARP1 [J].

Byers, Lauren Averett ;

Wang, Jing ;

Nilsson, Monique B. ;

Fujimoto, Junya ;

Saintigny, Pierre ;

Yordy, John ;

Giri, Uma ;

Peyton, Michael ;

Fan, You Hong ;

Diao, Lixia ;

Masrorpour, Fatemeh ;

Shen, Li ;

Liu, Wenbin ;

Duchemann, Boris ;

Tumula, Praveen ;

Bhardwaj, Vikas ;

Welsh, James ;

Weber, Stephanie ;

Glisson, Bonnie S. ;

Kalhor, Neda ;

Wistuba, Ignacio I. ;

Girard, Luc ;

Lippman, Scott M. ;

Mills, Gordon B. ;

Coombes, Kevin R. ;

Weinstein, John N. ;

Minna, John D. ;

Heymach, John V. .

CANCER DISCOVERY, 2012, 2 (09) :798-811

[6] Bolstering the Case for Lobectomy in Stages I, II, and IIIA Small-Cell Lung Cancer Using the National Cancer Data Base [J].

Combs, Susan E. ;

Hancock, Jacquelyn G. ;

Boffa, Daniel J. ;

Decker, Roy H. ;

Detterbeck, Frank C. ;

Kim, Anthony W. .

JOURNAL OF THORACIC ONCOLOGY, 2015, 10 (02) :316-323

[7] Chemosensitive Relapse in Small Cell Lung Cancer Proceeds through an EZH2-SLFN11 Axis [J].

Gardner, Eric E. ;

Lok, Benjamin H. ;

Schneeberger, Valentina E. ;

Desmeules, Patrice ;

Miles, Linde A. ;

Arnold, Paige K. ;

Ni, Andy ;

Khodos, Inna ;

de Stanchina, Elisa ;

Thuyen Nguyen ;

Sage, Julien ;

Campbell, John E. ;

Ribich, Scott ;

Rekhtman, Natasha ;

Dowlati, Afshin ;

Massion, Pierre P. ;

Rudin, Charles M. ;

Poirier, John T. .

CANCER CELL, 2017, 31 (02) :286-299

[8] Dysregulation of protein methyltransferases in human cancer: An emerging target class for anticancer therapy [J].

Hamamoto, Ryuji ;

Nakamura, Yusuke .

CANCER SCIENCE, 2016, 107 (04) :377-384

[9] Critical roles of non-histone protein lysine methylation in human tumorigenesis [J].

Hamamoto, Ryuji ;

Saloura, Vassiliki ;

Nakamura, Yusuke .

NATURE REVIEWS CANCER, 2015, 15 (02) :110-124

[10] Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients [J].

Herbst, Roy S. ;

Soria, Jean-Charles ;

Kowanetz, Marcin ;

Fine, Gregg D. ;

Hamid, Omid ;

Gordon, Michael S. ;

Sosman, Jeffery A. ;

McDermott, David F. ;

Powderly, John D. ;

Gettinger, Scott N. ;

Kohrt, Holbrook E. K. ;

Horn, Leora ;

Lawrence, Donald P. ;

Rost, Sandra ;

Leabman, Maya ;

Xiao, Yuanyuan ;

Mokatrin, Ahmad ;

Koeppen, Hartmut ;

Hegde, Priti S. ;

Mellman, Ira ;

Chen, Daniel S. ;

Hodi, F. Stephen .

NATURE, 2014, 515 (7528) :563-+

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