Urine Output Assessment in Acute Kidney Injury: The Cheapest and Most Impactful Biomarker

被引：26

作者：

Goldstein, Stuart L. ^{[1
,2
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Ctr Acute Care Nephrol, Cincinnati, OH 45229 USA

[2] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45221 USA

来源：

FRONTIERS IN PEDIATRICS | 2020年 / 7卷

关键词：

acute kidney injury; oliguria; children; fluid overload; epidemiology; SERUM CREATININE; CHILDREN; AKI; ASSOCIATION; OUTCOMES;

D O I：

10.3389/fped.2019.00565

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Acute kidney injury (AKI) is independently associated with morbidity and mortality in critically ill neonates, children, adolescents, and young adults. AKI occurs commonly in this population, and the vast majority of published studies utilize only a serum creatinine based criteria for AKI diagnosis and staging. While urine output criteria have been a part of all AKI systematic and multidimensional AKI definitions for the past 15 years, oliguria based on these definitions is difficult to extract from the electronic health record. This manuscript reviews the published data regarding the impact of oliguria on patient outcomes, and the contribution of oliguria to % fluid overload and resultant changes in serum creatinine based epidemiology. The aim of this manuscript is to demonstrate that oliguria is an incredibly valuable biomarker for the management of patients with, or at-risk for, AKI.

引用

页数：4

共 11 条

[1] Biomarkers of AKI: A Review of Mechanistic Relevance and Potential Therapeutic Implications [J].

Alge, Joseph L. ;

Arthur, John M. .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2015, 10 (01) :147-155

[2] Association Between Fluid Balance and Outcomes in Critically Ill Children A Systematic Review and Meta-analysis [J].

Alobaidi, Rashid ;

Morgan, Catherine ;

Basu, Rajit K. ;

Stenson, Erin ;

Featherstone, Robin ;

Majumdar, Sunlit R. ;

Bagshaw, Sean M. .

JAMA PEDIATRICS, 2018, 172 (03) :257-268

[3] Acute Kidney Injury Based on Corrected Serum Creatinine Is Associated With Increased Morbidity in Children Following the Arterial Switch Operation [J].

Basu, Rajit K. ;

Andrews, Anne ;

Krawczeski, Catherine ;

Manning, Peter ;

Wheeler, Derek S. ;

Goldstein, Stuart L. .

PEDIATRIC CRITICAL CARE MEDICINE, 2013, 14 (05) :E218-E224

[4] Foreword [J].

Eckardt, Kai-Uwe ;

Kasiske, Bertram L. .

KIDNEY INTERNATIONAL SUPPLEMENTS, 2012, 2 (01) :7-7

[5] Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study [J].

Hoste, Eric A. J. ;

Bagshaw, Sean M. ;

Bellomo, Rinaldo ;

Cely, Cynthia M. ;

Colman, Roos ;

Cruz, Dinna N. ;

Edipidis, Kyriakos ;

Forni, Lui G. ;

Gomersall, Charles D. ;

Govil, Deepak ;

Honore, Patrick M. ;

Joannes-Boyau, Olivier ;

Joannidis, Michael ;

Korhonen, Anna-Maija ;

Lavrentieva, Athina ;

Mehta, Ravindra L. ;

Palevsky, Paul ;

Roessler, Eric ;

Ronco, Claudio ;

Uchino, Shigehiko ;

Vazquez, Jorge A. ;

Vidal Andrade, Erick ;

Webb, Steve ;

Kellum, John A. .

INTENSIVE CARE MEDICINE, 2015, 41 (08) :1411-1423

[6] Incidence and outcomes of neonatal acute kidney injury (AWAKEN): a multicentre, multinational, observational cohort study [J].

Jetton, Jennifer G. ;

Boohaker, Louis J. ;

Sethi, Sidharth K. ;

Wazir, Sanjay ;

Rohatgi, Smriti ;

Soranno, Danielle E. ;

Chishti, Aftab S. ;

Woroniecki, Robert ;

Mammen, Cherry ;

Swanson, Jonathan R. ;

Sridhar, Shanthy ;

Wong, Craig S. ;

Kupferman, Juan C. ;

Griffin, Russell L. ;

Askenazi, David J. .

LANCET CHILD & ADOLESCENT HEALTH, 2017, 1 (03) :184-194

[7] Oliguria and Acute Kidney Injury in Critically Ill Children: Implications for Diagnosis and Outcomes [J].

Kaddourah, Ahmad ;

Basu, Rajit K. ;

Goldstein, Stuart L. ;

Sutherland, Scott M. .

PEDIATRIC CRITICAL CARE MEDICINE, 2019, 20 (04) :332-339

[8] Epidemiology of Acute Kidney Injury in Critically Ill Children and Young Adults [J].

Kaddourah, Ahmad ;

Basu, Rajit K. ;

Bagshaw, Sean M. ;

Goldstein, Stuart L. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (01) :11-20

[9] Classifying AKI by Urine Output versus Serum Creatinine Level [J].

Kellum, John A. ;

Sileanu, Florentina E. ;

Murugan, Raghavan ;

Lucko, Nicole ;

Shaw, Andrew D. ;

Clermont, Gilles .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2015, 26 (09) :2231-2238

[10] Acute kidney injury in patients with acute lung injury: Impact of fluid accumulation on classification of acute kidney injury and associated outcomes [J].

Liu, Kathleen D. ;

Thompson, B. Taylor ;

Ancukiewicz, Marek ;

Steingrub, Jay S. ;

Douglas, Ivor S. ;

Matthay, Michael A. ;

Wright, Patrick ;

Peterson, Michael W. ;

Rock, Peter ;

Hyzy, Robert C. ;

Anzueto, Antonio ;

Truwit, Jonathon D. .

CRITICAL CARE MEDICINE, 2011, 39 (12) :2665-2671

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