Psychopharmacological Effects of Alkaloid Z77 under Conditions of Posthypoxic Encephalopathy and Mechanisms of Their Development

被引：5

作者：

Zyuz'kov, G. N. ^{[1
,2
]}

Losev, E. A. ^{[1
]}

Chaikovskii, A. V. ^{[1
]}

Suslov, N. I. ^{[1
]}

Zhdanov, V. V. ^{[1
]}

Udut, E. V. ^{[1
]}

Miroshnichenko, L. A. ^{[1
]}

Simanina, E. V. ^{[1
]}

Polyakova, T. Yu. ^{[1
]}

Povet'eva, T. N. ^{[1
]}

Nesterova, Yu. V. ^{[1
]}

Stavrova, L. A. ^{[1
]}

Udut, V. V. ^{[1
,2
]}

Minakova, M. Yu. ^{[1
]}

Dygai, A. M. ^{[1
]}

机构：

[1] ED Goldberg Res Inst Pharmacol & Regenerat Med, Tomsk, Russia

[2] Tomsk Natl Res State Univ, Tomsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 161卷 / 01期

关键词：

regenerative medicine; cerebroprotective preparations; alkaloids; neural stem cells; hypoxia; MESENCHYMAL PROGENITOR CELLS; COLONY-STIMULATING FACTOR; FIBROBLAST-GROWTH-FACTOR; PRECURSOR CELLS; BRAIN ISCHEMIA; HYALURONIDASE; REALIZATION; MOBILIZATION; SONGORINE; PI3K;

D O I：

10.1007/s10517-016-3341-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Psychopharmacological effects of atisine-type diterpene alkaloid Z77 were studied under conditions of experimental posthypoxic encephalopathy. The preparation had a pronounced cerebroprotective effect consisting in normalization of orientation and exploratory behavior and conditioned activity in experimental animals. These changes were accompanied by significant increase in the number of neural stem cells in the paraventricular region of the brain and markedly enhanced production of neurotrophic growth factors by neural tissue microenvironment cells.

引用

页码：45 / 49

页数：5

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