Biomedical Photoacoustic Imaging for Molecular Detection and Disease Diagnosis: "Always-On" and "Turn-On" Probes

被引：32

作者：

Zeng, Yun ^{[1
,2
,3
,4
]}

Dou, Taotao ^{[5
]}

Ma, Lei ^{[6
]}

Ma, Jingwen ^{[7
]}

机构：

[1] Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710126, Shaanxi, Peoples R China

[2] Xidian Univ, Sch Life Sci & Technol, Xian 710126, Shaanxi, Peoples R China

[3] Xidian Univ, Int Joint Res Ctr Adv Med Imaging & Intelligent D, Xian 7100126, Shaanxi, Peoples R China

[4] Xidian Univ, Xian Key Lab Intelligent Sensing & Regulat TransS, Sch Life Sci & Technol, Xian 7100126, Shaanxi, Peoples R China

[5] Xi An Jiao Tong Univ, Affiliated Hosp Med Coll 9, Neurosurg Dept, Xian 710054, Shaanxi, Peoples R China

[6] Xi An Jiao Tong Univ, Vasc Intervent Dept, Affiliated Hosp 9, Coll Med, Xian 710054, Shaanxi, Peoples R China

[7] Xi An Jiao Tong Univ, Affiliated Hosp 9, Coll Med, CT & MRI Room,Dept Radiol, Xian 710054, Shaanxi, Peoples R China

来源：

ADVANCED SCIENCE | 2022年 / 9卷 / 25期

基金：

中国国家自然科学基金;

关键词：

biomedical imaging; diagnosis; nanoparticles; photoacoustic imaging; probes; SEMICONDUCTING POLYMER NANOPARTICLES; PHOTOTHERMAL CONVERSION EFFICIENCY; NEAR-INFRARED FLUORESCENCE; IN-VIVO; CONTRAST AGENTS; MAGNETIC-RESONANCE; GOLD NANOPARTICLES; THERAPY; NANOSPHERES; TOMOGRAPHY;

D O I：

10.1002/advs.202202384

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photoacoustic (PA) imaging is a nonionizing, noninvasive imaging technique that combines optical and ultrasonic imaging modalities to provide images with excellent contrast, spatial resolution, and penetration depth. Exogenous PA contrast agents are created to increase the sensitivity and specificity of PA imaging and to offer diagnostic information for illnesses. The existing PA contrast agents are categorized into two groups in this review: "always-on" and "turn-on," based on their ability to be triggered by target molecules. The present state of these probes, their merits and limitations, and their future development, is explored.

引用

页数：33

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