Stereoselective total synthesis of achaetolide and reconfirmation of its absolute configuration

被引：26
作者：
Srihari, P. [1 ]
Kumaraswamy, B. [1 ]
Shankar, P. [1 ]
Ravishashidhar, V. [1 ]
Yadav, J. S. [1 ]
机构：
[1] Indian Inst Chem Technol, Organ Div 1, CSIR, Hyderabad 500607, Andhra Pradesh, India
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 47期
关键词：
STAGONOSPORA-CIRSII; CHOLESTEROL-BIOSYNTHESIS; POTENTIAL MYCOHERBICIDE; SECONDARY METABOLITES; PHYTOTOXIC NONENOLIDE; PHOMA-HERBARUM; ALDEHYDES; FUNGUS; FAMILY; DECARESTRICTINES;
D O I：
10.1016/j.tetlet.2010.09.070
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The stereoselective total synthesis of achaetolide 1 has been achieved and its absolute stereochemistry has been reconfirmed to be 35,6R,7S,9R configuration. Keck allylation, Sharpless asymmetric dihydroxylation, and ring closing metathesis are the key steps involved in the target synthesis. (C) 2010 Elsevier Ltd. All rights reserved.
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收藏
页码：6174 / 6176
页数：3
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