Metabolic modeling of clostridia: current developments and applications

被引：37

作者：

Dash, Satyakam ^{[1
]}

Ng, Chiam Yu ^{[1
]}

Maranas, Costas D. ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem Engn, University Pk, PA 16802 USA

来源：

FEMS MICROBIOLOGY LETTERS | 2016年 / 363卷 / 04期

基金：

美国能源部;

关键词：

genome scale metabolic modeling; clostridia; solventogenic; cellulotytic; Wood-Ljungdahl pathway; GENOME-SCALE RECONSTRUCTION; BUTANOL-ETHANOL FERMENTATION; ESCHERICHIA-COLI; CELLULAR-METABOLISM; GENE ESSENTIALITY; KINETIC-MODEL; ACETOBUTYLICUM; NETWORK; EXPRESSION; STRAIN;

D O I：

10.1093/femsle/fnw004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Anaerobic Clostridium spp. is an important bioproduction microbial genus that can produce solvents and utilize a broad spectrum of substrates including cellulose and syngas. Genome-scale metabolic (GSM) models are increasingly being put forth for various clostridial strains to explore their respective metabolic capabilities and suitability for various bioconversions. In this study, we have selected representative GSM models for six different clostridia (Clostridium acetobutylicum, C. beijerinckii, C. butyricum, C. cellulolyticum, C. ljungdahlii and C. thermocellum) and performed a detailed model comparison contrasting their metabolic repertoire. We also discuss various applications of these GSM models to guide metabolic engineering interventions as well as assessing cellular physiology.

引用

页数：10

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