Optical coherence tomography angiography in diabetic patients without diabetic retinopathy

被引:22
作者
Furino, Claudio [1 ]
Montrone, Grazia [1 ]
Cicinelli, Maria Vittoria [2 ]
Balestra, Tefania [1 ]
Grassi, Mariaoliva [1 ]
Reibaldi, Michele [3 ]
Boscia, Francesco [4 ]
Alessio, Giovanni [1 ]
机构
[1] Azienda Osped Univ Policlin Vittorio Emanuele, Dept Ophthalmol, Piazza G Cesare 11, I-70124 Bari, Italy
[2] Univ Vita Salute, Sci Inst San Raffaele, Dept Ophthalmol, Milan, Italy
[3] Univ Catania, Eye Clin, Catania, Italy
[4] Univ Sassari, Eye Clin, Sassari, Italy
关键词
Diabetic retinopathy; optical coherence tomography angiography; foveal avascular zone; CAPILLARY PLEXUS; MELLITUS; DENSITY; VISION; EYES; PERIPAPILLARY; EPIDEMIOLOGY; DYSFUNCTION; IMPAIRMENT; PREVALENCE;
D O I
10.1177/1120672119895701
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To investigate a subset of diabetic patients without diabetic retinopathy with optical coherence tomography angiography, assessing the differences in macular perfusion between diseased eyes and healthy controls. Methods: Monocentric cross-sectional study, including 86 eyes from 43 diabetic patients with no clinical signs of diabetic retinopathy and 78 eyes from 39 controls. Patients underwent 3.0 x 3.0 mm and 4.5 x 4.5 mm swept-source optical coherence tomography angiography. Vessel density (%), foveal avascular zone area (mm(2)), and avascular density (%) were provided for the superficial capillary plexus and the deep capillary plexus. Results: The foveal avascular zone area at the superficial capillary plexus was larger in the study group compared to controls, irrespective of the area of the slab considered. A meaningful difference was found in the vessel density at the deep capillary plexus of the 3.0 x 3.0 mm slab (p = 0.03). Almost all the variables considered in the study showed a significant within-subject effect. Age significantly correlated with vessel density of superficial capillary plexus on 4.5 x 4.5 mm in both control and diabetic eyes. Conclusion: Diabetic patients with subclinical diabetic retinopathy feature a larger foveal avascular zone at the superficial capillary plexus compared with controls, as well as relative reduction of the vessel density at the deep capillary plexus. These findings might serve as the basis for screening between normal and diabetic subjects.
引用
收藏
页码:1418 / 1423
页数:6
相关论文
共 44 条
[31]   Early detection of diabetic retinopathy [J].
Safi, Hamid ;
Safi, Sare ;
Hafezi-Moghadam, Ali ;
Ahmadieh, Hamid .
SURVEY OF OPHTHALMOLOGY, 2018, 63 (05) :601-608
[32]   Deep capillary plexus impairment in patients with type1 diabetes mellitus with no signs of diabetic retinopathy revealed using optical coherence tomography angiography [J].
Scarinci, Fabio ;
Picconi, Fabiana ;
Giorno, Paola ;
Boccassini, Barbara ;
De Geronimo, Daniele ;
Varano, Monica ;
Frontoni, Simona ;
Parravano, Mariacristina .
ACTA OPHTHALMOLOGICA, 2018, 96 (02) :e264-e265
[33]   In Vivo Assessment of Macular Vascular Density in Healthy Human Eyes Using Optical Coherence Tomography Angiography [J].
Shahlaee, Abtin ;
Samara, Wasim A. ;
Hsu, Jason ;
Say, Emil Anthony T. ;
Khan, M. Ali ;
Sridhar, Jayanth ;
Hong, Bryan K. ;
Shields, Carol L. ;
Ho, Allen C. .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2016, 165 :39-46
[34]   Assessment of capillary dropout in the superficial retinal capillary plexus by optica coherence tomography angiography in the early stage of diabetic retinopathy [J].
Shen, Ceying ;
Yan, Shu ;
Du, Min ;
Zhao, Hong ;
Shao, Ling ;
Hu, Yibo .
BMC OPHTHALMOLOGY, 2018, 18
[35]   Reproducibility of Macular Vessel Density Calculations Via Imaging With Two Different Swept-Source Optical Coherence Tomography Angiography Systems [J].
Shoji, Takuhei ;
Yoshikawa, Yuji ;
Kanno, Junji ;
Ishii, Hirokazu ;
Ibuki, Hisashi ;
Ozaki, Kimitake ;
Kimura, Itaru ;
Shinoda, Kei .
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, 2018, 7 (06)
[36]   Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus [J].
Sohn, Elliott H. ;
van Dijk, Hille W. ;
Jiao, Chunhua ;
Kok, Pauline H. B. ;
Jeong, Woojin ;
Demirkaya, Nazli ;
Garmager, Allison ;
Wit, Ferdinand ;
Kucukevcilioglu, Murat ;
van Velthoven, Mirjam E. J. ;
DeVries, J. Hans ;
Mullins, Robert F. ;
Kuehn, Markus H. ;
Schlingemann, Reinier Otto ;
Sonka, Milan ;
Verbraak, Frank D. ;
Abramoffa, Michael David .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (19) :E2655-E2664
[37]  
Stanga PE, 2016, DEV OPHTHALMOL, V56, P13, DOI 10.1159/000442771
[38]   ENLARGEMENT OF FOVEAL AVASCULAR ZONE IN DIABETIC EYES EVALUATED BY EN FACE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY [J].
Takase, Noriaki ;
Nozaki, Miho ;
Kato, Aki ;
Ozeki, Hironori ;
Yoshida, Munenori ;
Ogura, Yuichiro .
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2015, 35 (11) :2377-2383
[39]   Factors associated with impaired color vision without retinopathy amongst people with type 2 diabetes mellitus: a cross-sectional study [J].
Tan, N. C. ;
Yip, W. F. ;
Kallakuri, S. ;
Sankari, U. ;
Koh, Y. L. E. .
BMC ENDOCRINE DISORDERS, 2017, 17
[40]   Quantitative Retinal Optical Coherence Tomography Angiography in Patients With Diabetes Without Diabetic Retinopathy [J].
Tang, Fangyao ;
Cheung, Carol Y. .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2017, 58 (03) :1766-1766