New sesquiterpene hydroperoxides with trypanocidal activity from Pogostemon cablin

被引：39

作者：

Kiuchi, F

Matsuo, K

Ito, M

Qui, TK

Honda, G

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

[2] Natl Inst Hlth Sci, Tsukuba Med Plant Res Stn, Tsukuba, Ibaraki 3050843, Japan

[3] Vietnam Natl Univ, Res Ctr Appl Chem, Ho Chi Minh City, Vietnam

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2004年 / 52卷 / 12期

关键词：

Pogostemon cablin; labiatae; sesquiterpene hydroperoxide; trypanocidal constitutent; Topanosoma cruzi;

D O I：

10.1248/cpb.52.1495

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1-3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1-3 against epimastigotes of Trypanosoma cruzi were 0.84 mum (1), 1.7mum (2) and 1.7 mum (3). The activity of the corresponding alcohols and patchouli alcohol was very weak (MLC > 200mum).

引用

页码：1495 / 1496

页数：2

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