Increasing Drug Resistance in Extensively Drug-Resistant Tuberculosis, South Africa

被引:43
作者
Shah, N. Sarita [1 ,2 ,3 ]
Richardson, Jessica [2 ,3 ]
Moodley, Prashini [4 ]
Moodley, Salona [4 ]
Babaria, Palav [2 ,5 ]
Ramtahal, Melissa [4 ]
Heysell, Scott K. [2 ]
Li, Xuan [3 ]
Moll, Anthony P. [2 ,6 ]
Friedland, Gerald [2 ,5 ]
Sturm, A. Willem [4 ]
Gandhi, Neel R. [2 ,3 ]
机构
[1] Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA
[2] Tugela Ferry Care & Res Collaborat, Tugela Ferry, South Africa
[3] Montefiore Med Ctr, Bronx, NY 10467 USA
[4] Nelson R Mandela Sch Med, Durban, South Africa
[5] Yale Univ, New Haven, CT USA
[6] Philanjalo Care Ctr, Tugela Ferry, South Africa
关键词
EMERGENCE;
D O I
10.3201/eid1703.101363
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We expanded second-line tuberculosis (TB) drug susceptibility testing for extensively drug-resistant Mycobacterium tuberculosis isolates from South Africa. Of 19 patients with extensively drug-resistant TB identified during February 2008 April 2009, 13 (68%) had isolates resistant to all 8 drugs tested. This resistance leaves no effective treatment with available drugs in South Africa.
引用
收藏
页码:510 / 513
页数:4
相关论文
共 12 条
  • [1] [Anonymous], 2010, WHO/HTM/TB/2010.3
  • [2] Emergence of Increased Resistance and Extensively Drug-Resistant Tuberculosis Despite Treatment Adherence, South Africa
    Calver, Alistair D.
    Falmer, Alecia A.
    Murray, Megan
    Strauss, Odelia J.
    Streicher, Elizabeth M.
    Hanekom, Madelene
    Liversage, Thelma
    Masibi, Mothusi
    van Helden, Paul D.
    Warren, Robin M.
    Victor, Thomas C.
    [J]. EMERGING INFECTIOUS DISEASES, 2010, 16 (02) : 264 - 271
  • [3] Emergence of Extensive Drug Resistance during Treatment for Multidrug-Resistant Tuberculosis
    Cox, Helen S.
    Sibilia, Katia
    Feuerriegel, Silke
    Kalon, Stobdan
    Polonsky, Jonny
    Khamraev, Atadjan K.
    Ruesch-Gerdes, Sabine
    Mills, Clair
    Niemann, Stefan
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (22) : 2398 - 2400
  • [4] Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa
    Gandhi, Neel R.
    Moll, Anthony
    Sturm, A. Willem
    Pawinski, Robert
    Govender, Thiloshini
    Lalloo, Umesh
    Zeller, Kimberly
    Andrews, Jason
    Friedland, Gerald
    [J]. LANCET, 2006, 368 (9547) : 1575 - 1580
  • [5] Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis
    Gandhi, Neel R.
    Nunn, Paul
    Dheda, Keertan
    Schaaf, H. Simon
    Zignol, Matteo
    van Soolingen, Dick
    Jensen, Paul
    Bayona, Jaime
    [J]. LANCET, 2010, 375 (9728) : 1830 - 1843
  • [6] HIV Coinfection in Multidrug- and Extensively Drug-Resistant Tuberculosis Results in High Early Mortality
    Gandhi, Neel R.
    Shah, N. Sarita
    Andrews, Jason R.
    Vella, Venanzio
    Moll, Anthony P.
    Scott, Michelle
    Weissman, Darren
    Marra, Claudio
    Lalloo, Umesh G.
    Friedland, Gerald H.
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2010, 181 (01) : 80 - 86
  • [7] Kam KM, 2010, INT J TUBERC LUNG D, V14, P282
  • [8] Laserson KF, 2005, INT J TUBERC LUNG D, V9, P640
  • [9] Comprehensive treatment of extensively drug-resistant tuberculosis
    Mitnick, Carole D.
    Shin, Sonya S.
    Seung, Kwonjune J.
    Rich, Michael L.
    Atwood, Sidney S.
    Furin, Jennifer J.
    Fitzmaurice, Garrett M.
    Alcantara Viru, Felix A.
    Appleton, Sasha C.
    Bayona, Jaime N.
    Bonilla, Cesar A.
    Chalco, Katiuska
    Choi, Sharon
    Franke, Molly F.
    Fraser, Hamish S. F.
    Guerra, Dalia
    Hurtado, Rocio M.
    Jazayeri, Darius
    Joseph, Keith
    Llaro, Karim
    Mestanza, Lorena
    Mukherjee, Joia S.
    Munoz, Maribel
    Palacios, Eda
    Sanchez, Epifanio
    Sloutsky, Alexander
    Becerra, Mercedes C.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (06) : 563 - 574
  • [10] Treatment outcomes among patients with multidrug-resistant tuberculosis: systematic review and meta-analysis
    Orenstein, Evan W.
    Basu, Sonjay
    Shah, N. Sarita
    Andrews, Jason R.
    Friedland, Gerald H.
    Moll, Anthony P.
    Gandhi, Neel R.
    Galvani, Alison P.
    [J]. LANCET INFECTIOUS DISEASES, 2009, 9 (03) : 153 - 161