SENTINEL1: Two-Season Study of Respiratory Syncytial Virus Hospitalizations among US Infants Born at 29 to 35 Weeks' Gestational Age Not Receiving Immunoprophylaxis

被引：34

作者：

Anderson, Evan J. ^{[1
,2
]}

DeVincenzo, John P. ^{[3
,4
]}

Simoes, Eric A. F. ^{[5
]}

Krilov, Leonard R. ^{[6
]}

Forbes, Michael L. ^{[7
]}

Pannaraj, Pia S. ^{[8
,9
]}

Espinosa, Claudia M. ^{[10
]}

Welliver, Robert C. ^{[11
]}

Wolkoff, Leslie I. ^{[12
]}

Yogev, Ram ^{[13
]}

Checchia, Paul A. ^{[14
]}

Domachowske, Joseph B. ^{[15
]}

Halasa, Natasha ^{[16
]}

McBride, Scott J. ^{[17
]}

Kumar, Veena R. ^{[18
]}

McLaurin, Kimmie K. ^{[18
]}

Rizzo, Christopher P. ^{[18
]}

Ambrose, Christopher S. ^{[18
]}

机构：

[1] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA

[2] Emory Univ, Sch Med, Dept Med, Atlanta, GA USA

[3] Univ Tennessee, Sch Med, Dept Pediat & Microbiol, Memphis, TN USA

[4] Univ Tennessee, Sch Med, Dept Immunol & Biochem, Memphis, TN USA

[5] Univ Colorado, Sch Med, Colorado Sch Publ Hlth, Childrens Hosp Colorado,Sect Pediat Infect Dis, Aurora, CO USA

[6] NYU, Winthrop Hosp, Childrens Med Ctr, Div Pediat Infect Dis, Mineola, NY USA

[7] Akron Childrens Hosp, Pediat Crit Care Med, Akron, OH 44308 USA

[8] Childrens Hosp Los Angeles, Div Infect Dis, Los Angeles, CA 90027 USA

[9] Univ Southern Calif, Keck Sch Med, Los Angeles, CA 90007 USA

[10] Univ Louisville, Pediat Infect Dis, Louisville, KY 40292 USA

[11] OU Med Ctr, Childrens Hosp, Pediat Infect Dis, Oklahoma City, OK USA

[12] Connecticut Childrens Med Ctr, Div Neonatol, Hartford, CT USA

[13] Northwestern Univ, Feinberg Sch Med, Ann & Robert H Lurie Childrens Hosp Chicago, Dept Pediat, Chicago, IL 60611 USA

[14] Texas Childrens Hosp, Cardiac Intens Care, Houston, TX 77030 USA

[15] SUNY Upstate Med Univ, Pediat Infect Dis, Syracuse, NY 13210 USA

[16] Vanderbilt Univ, Med Ctr, Pediat Infect Dis, Nashville, TN USA

[17] United BioSource Corp, Ann Arbor, MI USA

[18] AstraZeneca, Gaithersburg, MD USA

来源：

AMERICAN JOURNAL OF PERINATOLOGY | 2020年 / 37卷 / 04期

关键词：

respiratory syncytial virus; infants; palivizumab; immunoprophylaxis; hospitalizations; PRETERM INFANTS; PALIVIZUMAB; INFECTION; RISK; PREVENTION; CHILDREN; GUIDANCE; IMPACT;

D O I：

10.1055/s-0039-1681014

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective The SENTINEL1 observational study characterized confirmed respiratory syncytial virus hospitalizations (RSVH) among U.S. preterm infants born at 29 to 35 weeks' gestational age (wGA) not receiving respiratory syncytial virus (RSV) immunoprophylaxis (IP) during the 2014 to 2015 and 2015 to 2016 RSV seasons. Study Design All laboratory-confirmed RSVH at participating sites during the 2014 to 2015 and 2015 to 2016 RSV seasons (October 1-April 30) lasting >= 24 hours among preterm infants 29 to 35 wGA and aged Results Results were similar across the two seasons. Among infants with community-acquired RSVH ( N = 1,378), 45% were admitted to the intensive care unit (ICU) and 19% required invasive mechanical ventilation (IMV). There were two deaths. Infants aged <6 months accounted for 78% of RSVH observed, 84% of ICU admissions, and 91% requiring IMV. Among infants who were discharged from their birth hospitalization during the RSV season, 82% of RSVH occurred within 60 days of birth hospitalization discharge. Conclusion Among U.S. preterm infants 29 to 35 wGA not receiving RSV IP, RSVH are often severe with almost one-half requiring ICU admission and about one in five needing IMV.

引用

页码：421 / 429

页数：9

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