Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance

被引：195

作者：

Adorno-Cruz, Valery ^{[1
]}

Kibria, Golam ^{[1
]}

Liu, Xia ^{[1
]}

Doherty, Mary ^{[1
]}

Junk, Damian J. ^{[1
]}

Guan, Dongyin ^{[2
]}

Hubert, Chris ^{[3
]}

Venere, Monica ^{[4
]}

Mulkearns-Hubert, Erin ^{[5
]}

Sinyuk, Maksim ^{[5
]}

Alvarado, Alvaro ^{[5
]}

Caplan, Arnold I. ^{[6
,7
]}

Rich, Jeremy ^{[3
,7
,8
]}

Gerson, Stanton L. ^{[7
,8
,9
]}

Lathia, Justin ^{[5
,7
,8
]}

Liu, Huiping ^{[1
,7
,8
]}

机构：

[1] Case Western Reserve Univ, Sch Med, Dept Pathol, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH 44106 USA

[3] Cleveland Clin, Lerner Res Inst, Dept Stem Cell Biol & Regenerat Med, Cleveland, OH 44106 USA

[4] Cleveland Clin, Lerner Res Inst, Dept Canc Biol, Cleveland, OH 44106 USA

[5] Cleveland Clin, Lerner Res Inst, Dept Cellular & Mol Med, Cleveland, OH 44106 USA

[6] Case Western Reserve Univ, Sch Med, Dept Biol, Cleveland, OH 44106 USA

[7] Case Western Reserve Univ, Natl Ctr Regenerat Med, Cleveland, OH 44106 USA

[8] Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA

[9] Case Western Reserve Univ, Sch Med, Dept Med, Cleveland, OH 44106 USA

来源：

CANCER RESEARCH | 2015年 / 75卷 / 06期

关键词：

ACUTE MYELOID-LEUKEMIA; TRANSCRIPTION FACTOR; TUMOR-SUPPRESSOR; INITIATING CELLS; DIFFERENTIATION; HETEROGENEITY; PATHWAY; GROWTH; TUMORIGENICITY; IDENTIFICATION;

D O I：

10.1158/0008-5472.CAN-14-3225

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

With the goal to remove the roots of cancer, eliminate metastatic seeds, and overcome therapy resistance, the 2014 inaugural International Cancer Stem Cell (CSC) Conference at Cleveland, OH, convened together over 320 investigators, including 55 invited world-class speakers, 25 short oral presenters, and 100 poster presenters, to gain an in-depth understanding of CSCs and explore therapeutic opportunities targeting CSCs. The meeting enabled intriguing discussions on several topics including: genetics and epigenetics; cancer origin and evolution; microenvironment and exosomes; metabolism and inflammation; metastasis and therapy resistance; single cell and heterogeneity; plasticity and reprogramming; as well as other new concepts. Reports of clinical trials targeting CSCs emphasized the urgent need for strategically designing combinational CSC-targeting therapies against cancer. (C)2015 AACR.

引用

页码：924 / 929

页数：6

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