Cannabinoid dependence induces sustained changes in GABA release in the globus pallidus without affecting dopamine release in the dorsal striatum: A dual microdialysis probe study

被引：5

作者：

Moreno, Margarita ^{[1
,2
,3
]}

Decara, Juan ^{[4
]}

Javier Pavon, Francisco ^{[4
]}

Stouffer, David G. ^{[1
]}

Edwards, Scott ^{[1
]}

Serrano, Antonia ^{[4
]}

Suarez, Juan ^{[4
]}

Parsons, Loren H. ^{[1
]}

Rodriguez de Fonseca, Fernando ^{[4
]}

机构：

[1] Scripps Res Inst, Dept Neurosci, San Diego, CA USA

[2] Univ Almeria, Dept Psicol, Carretera Sacramento S-N, Almeria 04120, Spain

[3] Univ Almeria, CIAIMBITAL, CeiA3, Carretera Sacramento S-N, Almeria 04120, Spain

[4] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga, Unidad Gest Clin Salud Mental, Lab Neuropsicofarmacol, Malaga, Spain

来源：

ADDICTION BIOLOGY | 2018年 / 23卷 / 06期

关键词：

cannabinoid; dependence; dopamine; GABA; globus pallidum; microdialysis; rat; striatum; GABAERGIC NEUROTRANSMISSION; ENDOGENOUS CANNABINOIDS; RECEPTOR; DELTA(9)-TETRAHYDROCANNABINOL; INHIBITION; ACTIVATION; WITHDRAWAL; SENSITIZATION; EXPRESSION; PROTEINS;

D O I：

10.1111/adb.12694

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A dual probe microdialysis study was designed to characterize GABA and dopamine (DA) release in the basal ganglia of cannabinoid-dependent Wistar rats. Whereas chronic administration of the cannabinoid receptor agonist WIN55,212 (WIN) resulted in increased basal GABA release, the D2 agonist receptor-mediated control of GABA and DA release elicited by quinpirole was similar in both cannabinoid-dependent and non dependent animals. However, quinpirole did induce a greater number of more stereotypies in cannabinoid-dependent animals, indicating a dysregulated behavioral response.

引用

页码：1251 / 1261

页数：11

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