Peripheral artery disease is a common yet underdiagnosed cause of morbidity worldwide. Significant recent advances in management have resulted in new guideline creation for the diagnosis and management of peripheral artery disease in the United States and Europe. Here, we analyze each set of guidelines with special attention to those areas where the 2 groups disagree. Both groups emphasize the importance of risk factor reduction, including smoking cessation, lipid lowering, blood pressure management, and glucose control. The U.S. guidelines place additional attention on lifestyle factors, including regular physical activity and supervised exercise. The European guidelines offer a number of recommendations for revascularization in patients with limb-threatening ischemia. Both agree that more evidence is needed to understand which patients are at highest risk for tissue loss. A consistent charge to each committee fostering a similar approach to available data and more randomized studies would align recommendations across both organizations. (c) 2018 by the American College of Cardiology Foundation.
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Univ Wisconsin, Dept Med, Sch Med & Publ Hlth, Div Cardiovasc Med, Madison, WI USAUniv Wisconsin, Dept Med, Sch Med & Publ Hlth, Div Cardiovasc Med, Madison, WI USA
Goldberger, Zachary D.
Petek, Bradley J.
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Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USAUniv Wisconsin, Dept Med, Sch Med & Publ Hlth, Div Cardiovasc Med, Madison, WI USA
Petek, Bradley J.
Brignole, Michele
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Osped Tigullio, Dept Cardiol, Lavagna, ItalyUniv Wisconsin, Dept Med, Sch Med & Publ Hlth, Div Cardiovasc Med, Madison, WI USA
Brignole, Michele
Shen, Win-Kuang
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Mayo Clin, Dept Cardiol, Scottsdale, AZ USAUniv Wisconsin, Dept Med, Sch Med & Publ Hlth, Div Cardiovasc Med, Madison, WI USA
Shen, Win-Kuang
Sheldon, Robert S.
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Univ Calgary, Dept Cardiac Sci, Calgary, AB, CanadaUniv Wisconsin, Dept Med, Sch Med & Publ Hlth, Div Cardiovasc Med, Madison, WI USA
Sheldon, Robert S.
Solbiati, Monica
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Univ Milan, Fdn IRCCS Ca Granda, Osped Maggiore Policlin, Milan, ItalyUniv Wisconsin, Dept Med, Sch Med & Publ Hlth, Div Cardiovasc Med, Madison, WI USA
Solbiati, Monica
Deharo, Jean-Claude
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Hop La Timone, Dept Cardiol, Marseille, FranceUniv Wisconsin, Dept Med, Sch Med & Publ Hlth, Div Cardiovasc Med, Madison, WI USA
Deharo, Jean-Claude
Moya, Angel
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Hosp Univ Dexeus, Dept Cardiol, Barcelona, SpainUniv Wisconsin, Dept Med, Sch Med & Publ Hlth, Div Cardiovasc Med, Madison, WI USA
Moya, Angel
Hamdan, Mohamed H.
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Univ Wisconsin, Dept Med, Sch Med & Publ Hlth, Div Cardiovasc Med, Madison, WI USAUniv Wisconsin, Dept Med, Sch Med & Publ Hlth, Div Cardiovasc Med, Madison, WI USA
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Robert Packer Hosp, Guthrie Med Grp, Dept Cardiol, 1 Guthrie Sq, Sayre, PA 18840 USA
Geisinger Commonwealth Sch Med, Scranton, PA USARobert Packer Hosp, Guthrie Med Grp, Dept Cardiol, 1 Guthrie Sq, Sayre, PA 18840 USA
Singh, Maninder
Sporn, Zachary A.
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Geisinger Commonwealth Sch Med, Scranton, PA USARobert Packer Hosp, Guthrie Med Grp, Dept Cardiol, 1 Guthrie Sq, Sayre, PA 18840 USA
Sporn, Zachary A.
Schaff, Hartzell V.
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Mayo Clin, Dept Cardiovasc Surg, Rochester, MN USARobert Packer Hosp, Guthrie Med Grp, Dept Cardiol, 1 Guthrie Sq, Sayre, PA 18840 USA
Schaff, Hartzell V.
Pellikka, Patricia A.
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Mayo Clin, Dept Cardiovasc Med, Rochester, MN USARobert Packer Hosp, Guthrie Med Grp, Dept Cardiol, 1 Guthrie Sq, Sayre, PA 18840 USA
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Hosp Univ La Princesa, Dept Cardiol, Madrid, SpainUniv Catania, Azienda Osped Univ Policlin Vittorio Emanuele, Div Cardiol, CAST, PO G Rodol, Catania, Italy
Alfonso, Fernando
Levine, Glenn N.
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Baylor Coll Med, Dept Med, Houston, TX 77030 USAUniv Catania, Azienda Osped Univ Policlin Vittorio Emanuele, Div Cardiol, CAST, PO G Rodol, Catania, Italy
Levine, Glenn N.
Valgimigli, Marco
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Bern Univ Hosp, Bern, SwitzerlandUniv Catania, Azienda Osped Univ Policlin Vittorio Emanuele, Div Cardiol, CAST, PO G Rodol, Catania, Italy
Valgimigli, Marco
Angiolillo, Dominick J.
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Univ Florida, Coll Med, Div Cardiol, Jacksonville, FL USAUniv Catania, Azienda Osped Univ Policlin Vittorio Emanuele, Div Cardiol, CAST, PO G Rodol, Catania, Italy
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Kings Coll London, St Thomas Hosp, London, EnglandKings Coll London, St Thomas Hosp, London, England
Joseph, Jubin
Velasco, Alejandro
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Univ Alabama Birmingham, Div Cardiovasc Dis, Dept Med, Birmingham, AL USAKings Coll London, St Thomas Hosp, London, England
Velasco, Alejandro
Hage, Fadi G.
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Univ Alabama Birmingham, Div Cardiovasc Dis, Dept Med, Birmingham, AL USA
Birmingham Vet Affairs Med Ctr, Cardiol Sect, Birmingham, AL USAKings Coll London, St Thomas Hosp, London, England
Hage, Fadi G.
Reyes, Eliana
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Kings Coll London, St Thomas Hosp, London, England
Royal Brompton & Harefield NHS Fdn Trust, Dept Nucl Med, Sydney St, London SW3 6NP, EnglandKings Coll London, St Thomas Hosp, London, England
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Univ Chicago Med, Sect Endocrinol Diabet & Metab, AHA Comprehens Hypertens Ctr, Dept Med, Chicago, IL USAUniv Chicago Med, Sect Endocrinol Diabet & Metab, AHA Comprehens Hypertens Ctr, Dept Med, Chicago, IL USA
Bakris, George
Ali, Waleed
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Univ Chicago Med, Sect Endocrinol Diabet & Metab, AHA Comprehens Hypertens Ctr, Dept Med, Chicago, IL USAUniv Chicago Med, Sect Endocrinol Diabet & Metab, AHA Comprehens Hypertens Ctr, Dept Med, Chicago, IL USA