The receptor of the type I interferon family

被引：0
|
作者：
Uze, G. [1 ]
Schreiber, G. [2 ]
Piehler, J. [3 ]
Pellegrini, S. [4 ]
机构：
[1] Univ Montpellier 2, CNRS, UMR 5124, F-34095 Montpellier 5, France
[2] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel
[3] Goethe Univ Frankfurt, Inst Biochem, Bioctr N210, D-60439 Frankfurt, Germany
[4] Inst Pasteur, CNRS, URA 1961, Unit Cytokine Signaling, F-75015 Paris, France
来源：
INTERFERON: THE 50TH ANNIVERSARY | 2007年 / 316卷
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
All type I IFNs act through a single cell surface receptor composed of the IFNAR1 and IFNAR2 subunits and two associated cytoplasmic tyrosine kinases of the Janus family, Tyk2 and Jak1. A central issue in type I IFN biology is to understand how 1 a multitude of subtypes can generate similar signaling outputs but also govern specific 1 cellular responses. This review summarizes results from the last decade that contributed to our current state of knowledge of IFN-receptor complex structure and assembly.
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页码：71 / 95
页数：25
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