The receptor of the type I interferon family

被引：0

作者：

Uze, G. ^{[1
]}

Schreiber, G. ^{[2
]}

Piehler, J. ^{[3
]}

Pellegrini, S. ^{[4
]}

机构：

[1] Univ Montpellier 2, CNRS, UMR 5124, F-34095 Montpellier 5, France

[2] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel

[3] Goethe Univ Frankfurt, Inst Biochem, Bioctr N210, D-60439 Frankfurt, Germany

[4] Inst Pasteur, CNRS, URA 1961, Unit Cytokine Signaling, F-75015 Paris, France

来源：

INTERFERON: THE 50TH ANNIVERSARY | 2007年 / 316卷

关键词：

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

All type I IFNs act through a single cell surface receptor composed of the IFNAR1 and IFNAR2 subunits and two associated cytoplasmic tyrosine kinases of the Janus family, Tyk2 and Jak1. A central issue in type I IFN biology is to understand how 1 a multitude of subtypes can generate similar signaling outputs but also govern specific 1 cellular responses. This review summarizes results from the last decade that contributed to our current state of knowledge of IFN-receptor complex structure and assembly.

引用

页码：71 / 95

页数：25

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