Blood Transfusion and Risk of Venous Thromboembolism: A Population-Based Cohort Study

被引：39

作者：

Lin, Shih-Yi ^{[1
,2
,3
,4
]}

Chang, Yun-Lung ^{[1
,2
,3
,4
]}

Yeh, Hung-Chieh ^{[1
,2
,3
,4
]}

Lin, Cheng-Li ^{[5
,6
]}

Kao, Chia-Hung ^{[1
,2
,7
,8
,9
,10
]}

机构：

[1] China Med Univ, Grad Inst Biomed Sci, Coll Med, 2 Yuh Der Rd, Taichung 40447, Taiwan

[2] China Med Univ, Sch Med, Coll Med, 2 Yuh Der Rd, Taichung 40447, Taiwan

[3] China Med Univ Hosp, Div Nephrol, Taichung, Taiwan

[4] China Med Univ Hosp, Kidney Inst, Taichung, Taiwan

[5] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan

[6] China Med Univ, Coll Med, Taichung, Taiwan

[7] China Med Univ Hosp, Dept Nucl Med, Taichung, Taiwan

[8] China Med Univ Hosp, PET Ctr, Taichung, Taiwan

[9] China Med Univ Hosp, Ctr Augmented Intelligence Healthcare, Taichung, Taiwan

[10] Asia Univ, Dept Bioinformat & Med Engn, Taichung, Taiwan

来源：

THROMBOSIS AND HAEMOSTASIS | 2020年 / 120卷 / 01期

关键词：

venous thromboembolism; deep vein thrombosis; pulmonary embolism; blood transfusion; DEEP-VEIN THROMBOSIS; CELL TRANSFUSION; UNITED-STATES; TRANSMISSION; VIRUS; AGGREGATION; ASSOCIATION; HEMATOCRIT; MORTALITY; CORONARY;

D O I：

10.1055/s-0039-1697664

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background The risk of venous thromboembolism (VTE) in generally ill patients, both under outpatient and inpatient care, following blood transfusion has not been determined. Methods This retrospective population-based cohort study was conducted using the National Health Insurance Research Database. We studied patients who received blood transfusion, defined as red blood cell transfusion of any type, from January 1, 2000 to December 31, 2011. The index date was defined as the date of blood transfusion. The primary outcome was VTE. Propensity score matching and Cox proportional hazard models were used. Results A total of 41,866 patients who underwent blood transfusion and 41,866 matched controls were studied. Generally, the blood transfusion cohort has 2.98 times higher risk of VTE than the control cohort (95% confidence interval [CI] = 1.23-7.22). The blood transfusion cohort had respectively 1.99 and 1.64 times higher risk of deep vein thrombosis (DVT) and pulmonary embolism (PE) compared with the control cohort (DVT, 95% CI = 1.65-2.41; PE, 95% CI = 1.19-2.26). Patients in the blood transfusion cohort who did not use warfarin were 1.95 times more likely to develop VTE than those in the control cohort (adjusted hazard ratio [HR]: 1.95, 95% CI = 1.65-2.31). Patients in the blood transfusion cohort were 1.74 times more likely to die than those in the control cohort (adjusted HR: 1.74, 95% CI = 1.48-2.05). Conclusion Blood transfusion is associated with an increased risk of VTE. The risk of VTE decreased in those who took warfarin.

引用

页码：156 / 167

页数：12

共 48 条

[21] Congenital anomaly of the inferior vena cava and factor V Leiden mutation predisposing to deep vein thrombosis [J].