Exosomes as Drug Delivery Vehicles for Cancer Treatment

被引：13

作者：

Narayanan, Eshwaran ^{[1
]}

机构：

[1] Insys Dev Co, 410 S Benson Ln, Chandler, AZ 85224 USA

来源：

CURRENT NANOSCIENCE | 2020年 / 16卷 / 01期

关键词：

Extracellular vesicles; drug delivery; nanotechnology; targeted therapy; chemotherapy; nanocarriers; MESENCHYMAL STEM-CELLS; PROMOTE TUMOR-GROWTH; EXTRACELLULAR VESICLES; STROMAL CELLS; MEMBRANE-VESICLES; MEDIATED TRANSFER; IN-VITRO; MICROVESICLES; RECEPTOR; INHIBIT;

D O I：

10.2174/1573413715666190219112422

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Exosomes are nanoscale extracellular vesicles that encapsulate a diverse range of bin molecules such as nucleic acids, proteins, and lipids. They are involved in several biological processes and mediate intracellular communication. Recent reports that they exhibit unique traits in pathological conditions have generated significant interest in employing them as diagnostic and therapeutic tools. Particularly, their potential to serve as drug delivery vehicles for the treatment of cancer and other diseases has been explored in numerous studies. This manuscript reviews recent developments in the field and discusses important considerations for further refinement of this approach and realization of more effective exosome-based drug delivery systems.

引用

页码：15 / 26

页数：12

共 99 条

[1] Monocyte-derived microparticles and exosomes induce procoagulant and apoptotic effects on endothelial cells [J].

Aharon, Anat ;

Tamari, Tal ;

Brenner, Benjamin .

THROMBOSIS AND HAEMOSTASIS, 2008, 100 (05) :878-885

[2] Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies [J].

Akers, Johnny C. ;

Gonda, David ;

Kim, Ryan ;

Carter, Bob S. ;

Chen, Clark C. .

JOURNAL OF NEURO-ONCOLOGY, 2013, 113 (01) :1-11

[3] Intercellular transfer of the oncogenic receptor EGFrvIII by microvesicles derived from tumour cells [J].

Al-Nedawi, Khalid ;

Meehan, Brian ;

Micallef, Johann ;

Lhotak, Vladimir ;

May, Linda ;

Guha, Abhijit ;

Rak, Janusz .

NATURE CELL BIOLOGY, 2008, 10 (05) :619-U24

[4] Exosome-delivered microRNAs modulate the inflammatory response to endotoxin [J].

Alexander, Margaret ;

Hu, Ruozhen ;

Runtsch, Marah C. ;

Kagele, Dominique A. ;

Mosbruger, Timothy L. ;

Tolmachova, Tanya ;

Seabra, Miguel C. ;

Round, June L. ;

Ward, Diane M. ;

O'Connell, Ryan M. .

NATURE COMMUNICATIONS, 2015, 6

[5] Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes [J].

Alvarez-Erviti, Lydia ;

Seow, Yiqi ;

Yin, HaiFang ;

Betts, Corinne ;

Lakhal, Samira ;

Wood, Matthew J. A. .

NATURE BIOTECHNOLOGY, 2011, 29 (04) :341-U179

[6] Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases? [J].

Bellingham, Shayne A. ;

Guo, Belinda B. ;

Coleman, Bradley M. ;

Hill, Andrew F. .

FRONTIERS IN PHYSIOLOGY, 2012, 3

[7] Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity [J].

Bryniarski, Krzysztof ;

Ptak, Wlodzimierz ;

Jayakumar, Asha ;

Puellmann, Kerstin ;

Caplan, Michael J. ;

Chairoungdua, Arthit ;

Lu, Jun ;

Adams, Brian D. ;

Sikora, Emilia ;

Nazimek, Katarzyna ;

Marquez, Susanna ;

Kleinstein, Steven H. ;

Sangwung, Panjamaporn ;

Iwakiri, Yasuko ;

Delgato, Eric ;

Redegeld, Frank ;

Blokhuis, Bart R. ;

Wojcikowski, Jacek ;

Daniel, Wladyslawa Anna ;

Kormelink, Tom Groot ;

Askenase, Philip W. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2013, 132 (01) :170-+

[8] Calcium induces phospholipid redistribution and microvesicle release in human erythrocyte membranes by independent pathways [J].

Bucki, R ;

Bachelot-Loza, C ;

Zachowski, A ;

Giraud, F ;

Sulpice, JC .

BIOCHEMISTRY, 1998, 37 (44) :15383-15391

[9]

Camussi G, 2011, AM J CANCER RES, V1, P98

[10] Exosomes: immune properties and potential clinical implementations [J].

Chaput, Nathalie ;

Thery, Clotilde .

SEMINARS IN IMMUNOPATHOLOGY, 2011, 33 (05) :419-440

← 1 2 3 4 5 6 7 8 9 10 →