Baseline serum level of matrix metalloproteinase-3 as a biomarker of progressive joint damage in rheumatoid arthritis patients

被引:41
作者
Galil, Sahar Mahfouz Abdel [1 ,4 ]
El-Shafey, Abeer Mohamed [1 ]
Hagrass, Hoda A. [2 ]
Fawzy, Faten [3 ]
El Sammak, Ahmed [3 ]
机构
[1] Zagazig Univ, Fac Med, Dept Rheumatol & Rehabil, Zagazig, Egypt
[2] Zagazig Univ, Fac Med, Dept Clin Pathol, Zagazig, Egypt
[3] Zagazig Univ, Fac Med, Dept Radiol, Zagazig, Egypt
[4] Umm Al Qura Univ, Fac Med, Dept Med, Holly Markkah, Saudi Arabia
关键词
matrix metalloproteinase-3; prognostic marker; rheumatoid arthritis; RADIOGRAPHIC DAMAGE; TISSUE INHIBITOR; DISEASE-ACTIVITY; MMP-3; MRI; MATRIX-METALLOPROTEINASE-3; CLASSIFICATION; DESTRUCTION; COMBINATION; EROSIONS;
D O I
10.1111/1756-185X.12434
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aim: Matrix metalloproteinase-3 (MMP-3) plays a pivotal role in the destruction of bone and degradation of cartilage components in rheumatoid arthritis (RA). We aimed in this study to analyze the relation between baseline levels of MMP-3 and the progression of joint damage in RA. Methods: Eighty-one untreated RA patients with joint symptoms for <1 year were evaluated at baseline and after 12 months as regards erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP) and plain X-ray of both hands and wrists. Baseline levels of MMP-3 were measured by enzyme-linked immunosorbent assay and magnetic resonance imaging (MRI) of hands/wrists was performed. Disease Activity Score (DAS28) and Health Assessment Questionnaire (HAQ) were performed at baseline evaluation and after 12 months. Results: The baseline MMP-3 levels were significantly higher in the high-progression group compared with the low-progression one (95.75 +/- 42.84 vs. 50.45 +/- 12.83, P < 0.001). There was a positive correlation between baseline levels of MMP-3 and MRI erosion score and other baseline clinical parameters, except for HAQ and the van der Heijde modification of the Sharp scoring system (SvdH) scores, while after 12 months, there were high positive correlations between MMP-3 and SvdH score, as well as all parameters except for ESR. Conclusion: Serum baseline levels of MMP-3 are strong prognostic markers of disease activity, and act well as an early predictor of progressive joint damage in recent-onset RA disease.
引用
收藏
页码:377 / 384
页数:8
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