The first synthesis of the Streptomyces derived antibiotic U-62162

被引：7

作者：

Alcaraz, L ^{[1
]}

Taylor, RJK ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO1 5DD, N Yorkshire, England

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 10期

关键词：

D O I：

10.1039/a801265b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

U-62162, a member of the manumycin family of antibiotics, has been prepared as a mixture of diastereoisomers and shown to contain a syn-hydroxy epoxide nucleus and a 1,3-syn-disposed dimethyl unit in the upper side chain; the cornerstone of the synthetic route utilises organometallic addition to a monoprotected quinone epoxide-the first time this approach has been successfully employed to prepare a manumycin antibiotic.

引用

页码：1157 / 1158

页数：2

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