Impact of positive surgical margins on prostate cancer prognosis

被引：0

作者：

Kayombo, R. Tambwe ^{[1
]}

Leon, P. ^{[2
]}

Lasserre, T. ^{[3
]}

Fournier, R. ^{[4
]}

Branchu, B. ^{[1
]}

Hulin, M. ^{[1
]}

Durlach, A. ^{[5
]}

Larre, S. ^{[1
]}

机构：

[1] CHU Reims, Serv Urol, F-51100 Reims, France

[2] Clin Pasteur, Serv Urol, F-17200 Royan, France

[3] CMC Les Cedres, Serv Urol, F-19100 Brive, France

[4] Ctr Urol Trenel, Serv Urol, F-69560 St Colombe, France

[5] CHU Reims, Lab Anatomopathol, F-51100 Reims, France

来源：

PROGRES EN UROLOGIE | 2021年 / 31卷 / 12期

关键词：

Prostate neoplasms; Radical Prostatectomy; Positive surgical margins; Biochemical recurrence; Survival; RADICAL PROSTATECTOMY; RADIATION-THERAPY; RADIOTHERAPY; UPDATE;

D O I：

10.1016/j.purol.2020.11.009

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. - To examine the impact of positive surgical margins (PSM) after radical prostatectomy (RP) for prostate cancer on oncological results. Patients and methods. - We performed a study where all patients who underwent radical prostatectomy between January 2004 and December 2018 for prostate cancer were included. The preoperative, postoperative data and the carcinological results collected were analyzed. Data were analysed using Kaplan-Meier survival analysis and proportional hazards models. Results. - A total of 319 patients with a median age of 65 years (IQR : 62-69) were included. The median follow-up was 43.6 months (IQR: 19.4-79.3). The overall rate of PSM was 33.5%. PSM was associated with biochemical recurrence (P < 0.001). Overall mortality was not associated with positive margins. A clinical stage> T1c was an independent predictor of PSM on multivariate analysis (P = 0.01). Conclusion. - PSM would increase the risk of biochemical recurrence with no impact on survival. Clinical stage > T1c was an adverse predictor for PSM. (C) 2020 Elsevier Masson SAS. All rights reserved.

引用

页码：709 / 715

页数：7

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