SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SOME α-AMINOPHOSPHONATES

被引：0

作者：

Onita, Nicolae ^{[1
]}

Sisu, Ioana ^{[1
]}

Penescu, Mircea ^{[3
,4
]}

Purcarea, Victor Lorin ^{[4
]}

Kurunczi, Ludovic ^{[1
,2
]}

机构：

[1] Romanian Acad, Inst Chem Timisoara, Timisoara 300223, Romania

[2] Univ Med & Pharm Victor Babes Timisoara, Fac Pharm, Timisoara 300041, Romania

[3] Carol Davila Hosp Nephrol, Bucharest 010701, Romania

[4] Univ Med & Pharm Carol Davila, Bucharest 020021, Romania

来源：

FARMACIA | 2010年 / 58卷 / 05期

关键词：

alpha-aminophosphonates; antioxidant activity; DPPH center dot; erythrocytes; hemolytic activity; DERIVATIVES; POTENT; ACIDS;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A series of 12 aminophosphonates (AMPP) were synthesized, characterized and tested for their potential biological activity. The antioxidant activity was tested in experimental assays with DPPH center dot (1,1-diphenyl-2-picryl-hydrazyl) and the potential to function as herbicides, in red blood cells (RBC) membrane destruction experiments. Regarding the reaction with DPPH center dot at least 3 aminophosphonates are better antioxidants than 2,6-di-tert-butyl-4-methylphenol (BHT). Aminophosphonates' capacity to function as herbicide (demonstrated through their hemolytic activity) is given by the presence in their structure of some shorter aliphatic substituents and / or more benzenic nuclei.

引用

页码：531 / 545

页数：15

共 31 条

[1]

Anderson R. J., 2004, ORGANIC SPECTROSCOPI, V22, P7

[2] SYNTHESIS AND PROPERTIES OF NOVEL NITROGEN-MUSTARD LINKED PHOSPHORYL DIAMIDE DERIVATIVES [J].

CHEN, RY ;

MAO, LJ ;

WANG, HL ;

ZHOU, J .

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1994, 89 (1-4) :89-95

[3]

Farkas E., 2002, AMINO ACIDS PEP PROT, V32, P295

[4] Synthesis and biological evaluation of γ-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists [J].

Foss, Frank W., Jr. ;

Snyder, Ashley H. ;

Davis, Michael D. ;

Rouse, Michael ;

Okusa, Mark D. ;

Lynch, Kevin R. ;

Macdonald, Timothy L. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2007, 15 (02) :663-677

[5] N,N′-Ethylenediaminobis(benzylphosphonic acids) as a potent class of chelators for metal ions [J].

Galezowska, Joanna ;

Kafarski, Pawel ;

Kozlowski, Henryk ;

Mlynarz, Piotr ;

Nurchi, Valeria M. ;

Pivetta, Tiziana .

INORGANICA CHIMICA ACTA, 2009, 362 (03) :707-713

[6] Free radical scavenging activity of gossypin and nevadensin:: An in-vitro evaluation [J].

Ganapaty, S. ;

Chandrashekhar, V. M. ;

Chitme, H. R. ;

Narsu, M. Lakashmi .

INDIAN JOURNAL OF PHARMACOLOGY, 2007, 39 (06) :281-283

[7] A critical comparison of the hemolytic and fungicidal activities of cationic antimicrobial peptides [J].

Helmerhorst, EJ ;

Reijnders, IM ;

van't Hof, W ;

Veerman, ECI ;

Amerongen, AVN .

FEBS LETTERS, 1999, 449 (2-3) :105-110

[8] Organophosphorus compounds as potential fungicides. Part VI. Preparation, characterization, and biological activity of analogues and derivatives of 1-aminopropanephosphonic acid [J].

Hudson, HR ;

Ismail, F ;

Pianka, M .

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2001, 173 :143-162

[9] Spectroscopic and DFT study of 3-quinolyl-α-aminophosphonates [J].

Juribasic, Marina ;

Tusek-Bozic, Ljerka .

JOURNAL OF MOLECULAR STRUCTURE, 2009, 924 :66-72

[10]

Kleszczynska H, 2000, CELL MOL BIOL LETT, V5, P415

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