Angiogenesis - Where do we stand now?

被引：338
作者：
Simons, M
机构：
[1] Dartmouth Coll Sch Med, Dartmouth Hitchcock Med Ctr, Cardiol Sect, Dept Med, Lebanon, NH 03756 USA
[2] Dartmouth Coll Sch Med, Dartmouth Hitchcock Med Ctr, Angiogenesis Res Ctr, Lebanon, NH 03756 USA
[3] Dartmouth Coll Sch Med, Dartmouth Hitchcock Med Ctr, Cardiol Sect, Dept Pharmacol & Toxicol, Lebanon, NH 03756 USA
来源：
CIRCULATION | 2005年 / 111卷 / 12期
关键词：
angiogenesis; genetics; hypoxia; pharmacokinetics; imaging;
D O I：
10.1161/01.CIR.0000159345.00591.8F
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Therapeutic modulation of angiogenesis is still in its infancy, but the baby is showing considerable potential. The ultimate success of this therapeutic modality will depend on careful translational research program that will incorporate the ever-evolving basic understanding of the biology of angiogenesis into an effective clinical trials program. The likely keys include the careful choice of a biological agent that may be different for different indications, effective delivery modality with pharmacokinetic properties matching biological needs, and the meticulous choice of patient population and end points for study. © 2005 American Heart Association, Inc.
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收藏
页码：1556 / 1566
页数：11
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