Investigations into the synthesis of amine-linked neodisaccharides

被引：21

作者：

Akhtar, Tashfeen ^{[1
]}

Cumpstey, Ian ^{[1
]}

机构：

[1] Univ Stockholm, Arrhenius Lab, Dept Organ Chem, S-10691 Stockholm, Sweden

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 49期

关键词：

aminosugars; disaccharides; carbohydrates; glycomimetics;

D O I：

10.1016/j.tetlet.2007.10.039

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Six tail-to-tail amine-linked neodisaccharides were synthesised as potential glycomimetics. Primary-primary linked compounds were synthesised using Mitsunobu chemistry with glucose-6-sulfonamides as nucleophiles and primary carbohydrate alcohols as electrophiles. Primary-secondary linked compounds were synthesised by epoxide ring opening with carbohydrate 6-amines. Deprotection of all neodisaccharides was carried out using dissolving metal reduction. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：8673 / 8677

页数：5

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