Adrenomedullin: A Novel Therapeutic for the Treatment of Inflammatory Bowel Disease

被引：23
作者：
Ashizuka, Shinya [1 ]
Kita, Toshihiro [2 ]
Inatsu, Haruhiko [1 ]
Kitamura, Kazuo [2 ]
机构：
[1] Univ Miyazaki, Fac Med, Dept Internal Med, Div Gastroenterol & Hepatol, Miyazaki 8891692, Japan
[2] Univ Miyazaki, Frontier Sci Res Ctr, Dept Projects Res, Miyazaki 8891692, Japan
来源：
BIOMEDICINES | 2021年 / 9卷 / 08期
关键词：
adrenomedullin; inflammatory bowel disease; ulcerative colitis; Crohn's disease; translational research; drug discovery research; EPITHELIAL BARRIER FUNCTION; ULCERATIVE-COLITIS; EXPRESSION; INDUCTION;
D O I：
10.3390/biomedicines9081068
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Adrenomedullin (AM) is a bioactive peptide with various physiological functions, including vasodilation, angiogenesis, anti-inflammation, organ protection, and tissue repair. AM suppresses inflammatory cytokine production in the intestinal mucosa, improves vascular and lymphatic regeneration and function, mucosal epithelial repair, and immune function in the intestinal bacteria of animal models with intestinal inflammation. We have been promoting translational research to develop novel therapeutic agents for inflammatory bowel disease (IBD) using AM and have started clinical research for IBD patients since 2010. A multicenter clinical trial is currently underway in Japan for patients with refractory ulcerative colitis and Crohn's disease. Moreover, since current AM administration is limited to continuous intravenous infusion, the development of a subcutaneous formulation using long-acting AM is underway for outpatient treatment.
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页数：12
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