The magnitude of association between overweight and obesity and the risk of diabetes: A meta-analysis of prospective cohort studies

被引：532
作者：
Abdullah, Asnawi [1 ]
Peeters, Anna [1 ]
de Courten, Maximilian [1 ]
Stoelwinder, Johannes [1 ]
机构：
[1] Monash Univ, Sch Publ Hlth & Prevent Med, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia
来源：
DIABETES RESEARCH AND CLINICAL PRACTICE | 2010年 / 89卷 / 03期
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
Obesity; BMI; Meta-analysis; Type; 2; diabetes; BODY-MASS INDEX; FAT DISTRIBUTION; WAIST CIRCUMFERENCE; WEIGHT CHANGE; FOLLOW-UP; MELLITUS; TYPE-2; WOMEN; SEX; HYPERTENSION;
D O I：
10.1016/j.diabres.2010.04.012
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The objectives of this meta-analysis were to examine the magnitude of the relative risk (RR) of developing type 2 diabetes for overweight and obese populations, compared to those with normal weight, and to determine causes of the variation in RR between various cohort studies. The magnitude of the RR was analyzed by combining 18 prospective cohort studies that matched defined criteria. The variance in RR between studies was explored. The overall RR of diabetes for obese persons compared to those with normal weight was 7.19, 95% CI: 5.74, 9.00 and for overweight was 2.99, 95% CI: 2.42, 3.72. The variation in RR among studies was explored and it was found that the effect of heterogeneity was highly related with sample size, method of assessment of body mass index (BMI) and method of ascertainment of type 2 diabetes. By combining only cohort studies with more than 400 cases of incident diabetes (>median), adjusted by at least three main confounding variables (age, family history of type 2 diabetes, physical activity), measured BMI, and diabetes determined by clinical diagnosis, the RR was 7.28, 95% CI: 6.47, 8.28 for obesity and 2.92, 95% CI: 2.57, 3.32 for overweight. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：309 / 319
页数：11
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