HIV Drug Resistance in Adults Failing Early Antiretroviral Treatment: Results From the HIV Prevention Trials Network 052 Trial

被引：11

作者：

Fogel, Jessica M. ^{[1
]}

Hudelson, Sarah E. ^{[1
]}

Ou, San-San ^{[2
]}

Hart, Stephen ^{[3
]}

Wallis, Carole ^{[4
,5
]}

Morgado, Mariza G. ^{[6
]}

Saravanan, Shanmugam ^{[7
]}

Tripathy, Srikanth ^{[8
]}

Hovind, Laura ^{[3
]}

Piwowar-Manning, Estelle ^{[1
]}

Sabin, Devin ^{[1
]}

McCauley, Marybeth ^{[9
]}

Gamble, Theresa ^{[10
]}

Zhang, Xinyi C. ^{[2
]}

Eron, Joseph J. ^{[11
]}

Gallant, Joel E. ^{[12
]}

Kumwenda, Johnstone ^{[13
]}

Makhema, Joseph ^{[14
]}

Kumarasamy, Nagalingeswaran ^{[15
]}

Chariyalertsak, Suwat ^{[16
]}

Hakim, James ^{[17
]}

Badal-Faesen, Sharlaa ^{[18
]}

Akelo, Victor ^{[19
]}

Hosseinipour, Mina C. ^{[20
,21
]}

Santos, Breno R. ^{[22
]}

Godbole, Sheela V. ^{[23
]}

Pilotto, Jose H. ^{[24
,25
]}

Grinsztejn, Beatriz ^{[26
]}

Panchia, Ravindre ^{[27
]}

Mayer, Kenneth H. ^{[28
,29
]}

Chen, Ying Q. ^{[30
,31
]}

Cohen, Myron S. ^{[11
]}

Eshleman, Susan H. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[2] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, 1124 Columbia St, Seattle, WA 98104 USA

[3] Frontier Sci & Technol Res Fdn Inc, Amherst, NY USA

[4] Lancet Labs, Specialty Mol Div, Johannesburg, South Africa

[5] BARC SA, Johannesburg, South Africa

[6] Inst Oswaldo Cruz, Lab AIDS & Mol Immunol, BR-20001 Rio De Janeiro, Brazil

[7] YR Gaitonde Ctr AIDS Res & Educ, Chennai, Tamil Nadu, India

[8] Natl JALMA Inst Leprosy & Other Mycobacterial Dis, Agra, Uttar Pradesh, India

[9] FHI 360, Sci Facilitat Dept, Washington, DC USA

[10] FHI 360, Sci Facilitat Dept, Durham, NC USA

[11] Univ N Carolina, Dept Med, Chapel Hill, NC USA

[12] Southwest CARE Ctr, Santa Fe, NM USA

[13] Johns Hopkins Project, Coll Med, Blantyre, Malawi

[14] Botswana Harvard AIDS Inst, Gaborone, Botswana

[15] VHS, YRGCARE Med Ctr, Chennai, Tamil Nadu, India

[16] Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai 50000, Thailand

[17] Univ Zimbabwe, Dept Med, Harare, Zimbabwe

[18] Univ Witwatersrand, Wits Reprod Hlth & HIV Inst, Johannesburg, South Africa

[19] Ctr Dis Control, Kenya Med Res Inst, Kisumu, Kenya

[20] Univ N Carolina, Div Infect Dis, Chapel Hill, NC USA

[21] UNC Project Malawi, Inst Global Hlth & Infect Dis, Lilongwe, Malawi

[22] Hosp Nossa Senhora da Conceicao, Serv Infectol, Porto Alegre, RS, Brazil

[23] Natl AIDS Res Inst ICMR, Dept Epidemiol & Biostat, Pune, Maharashtra, India

[24] Hosp Geral de Nova Iguacu, Rio De Janeiro, Brazil

[25] Fiocruz MS, Lab AIDS & Imunol Mol IOC, BR-21045900 Rio De Janeiro, Brazil

[26] Fiocruz MS, Inst Nacl Infectol Evandro Chagas INI, BR-21045900 Rio De Janeiro, Brazil

[27] Univ Witwatersrand, Soweto HPTN CRS, Perinatal HIV Res Unit, Soweto, South Africa

[28] Fenway Inst, Fenway Hlth & Infect Dis Div, Boston, MA USA

[29] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Med, Boston, MA 02215 USA

[30] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, 1124 Columbia St, Seattle, WA 98104 USA

[31] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2016年 / 72卷 / 03期

基金：

美国国家卫生研究院;

关键词：

HIV; HPTN; 052; early ART; ART failure; resistance; CELL COUNTS; THERAPY; INFECTION; INITIATION; FAILURE; MUTATIONS;

D O I：

10.1097/QAI.0000000000000951

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Early initiation of antiretroviral treatment (ART) reduces HIV transmission and has health benefits. HIV drug resistance can limit treatment options and compromise use of ART for HIV prevention. We evaluated drug resistance in 85 participants in the HIV Prevention Trials Network 052 trial who started ART at CD4 counts of 350-550 cells per cubic millimeter and failed ART by May 2011; 8.2% had baseline resistance and 35.3% had resistance at ART failure. High baseline viral load and less education were associated with emergence of resistance at ART failure. Resistance at ART failure was observed in 7 of 8 (87.5%) participants who started ART at lower CD4 cell counts.

引用

页码：304 / 309

页数：6

共 22 条

[1] [Anonymous], 2015, MAX TREATM PREV POT
[2] [Anonymous], GUIDELINES USE ANTIR
[3] [Anonymous], 8 IAS C HIV PATH TRE
[4] Prevention of HIV-1 Infection with Early Antiretroviral Therapy
Cohen, Myron S.
Chen, Ying Q.
McCauley, Marybeth
Gamble, Theresa
Hosseinipour, Mina C.
Kumarasamy, Nagalingeswaran
Hakim, James G.
Kumwenda, Johnstone
Grinsztejn, Beatriz
Pilotto, Jose H. S.
Godbole, Sheela V.
Mehendale, Sanjay
Chariyalertsak, Suwat
Santos, Breno R.
Mayer, Kenneth H.
Hoffman, Irving F.
Eshleman, Susan H.
Piwowar-Manning, Estelle
Wang, Lei
Makhema, Joseph
Mills, Lisa A.
de Bruyn, Guy
Sanne, Ian
Eron, Joseph
Gallant, Joel
Havlir, Diane
Swindells, Susan
Ribaudo, Heather
Elharrar, Vanessa
Burns, David
Taha, Taha E.
Nielsen-Saines, Karin
Celentano, David
Essex, Max
Fleming, Thomas R.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (06) : 493 - 505
[5] A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa
Danel, Christine
Moh, Raoul
Gabillard, Delphine
Badje, Anani
Le Carrou, Jerome
Ouassa, Timothee
Ouattara, Eric
Anzian, Amani
Ntakpe, Jean-Baptiste
Minga, Albert
Kouame, Gerard M.
Bouhoussou, Franck
Emieme, Arlette
Kouame, Antoine
Inwoley, Andre
Toni, Thomas-d'Aquin
Ahiboh, Hugues
Kabran, Mathieu
Rabe, Cyprien
Sidibe, Baba
Nzunetu, Gustave
Konan, Romuald
Gnokoro, Joachim
Gouesse, Patrice
Messou, Eugene
Dohoun, Lambert
Kamagate, Synali
Yao, Abo
Amon, Solange
Kouame, Amadou-Barenson
Koua, Aboli
Kouame, Emmanuel
Ndri, Yao
Ba-Gomis, Olivier
Daligou, Marcelle
Ackoundze, Simplice
Hawerlander, Denise
Ani, Alex
Dembele, Fassery
Guehi, Calixte
Kanga, Constance
Seri, Jonas
Oyebi, Mykayila
Mbakop, Nathalie
Makaila, Olewole
Babatunde, Carole
Babatounde, Nathanael
Bleoue, Gisele
Tchoutedjem, Mireille
Kouadio, Alain-Claude
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (09) : 808 - 822
[6] Undisclosed Antiretroviral Drug Use in a Multinational Clinical Trial (HIV Prevention Trials Network 052)
Fogel, Jessica M.
Wang, Lei
Parsons, Teresa L.
Ou, San-San
Piwowar-Manning, Estelle
Chen, Ying
Mudhune, Victor O.
Hosseinipour, Mina C.
Kumwenda, Johnstone
Hakim, James G.
Chariyalertsak, Suwat
Panchia, Ravindre
Sanne, Ian
Kumarasamy, Nagalingeswaran
Grinsztejn, Beatriz
Makhema, Joseph
Pilotto, Jose
Santos, Breno R.
Mayer, Kenneth H.
McCauley, Marybeth
Gamble, Theresa
Bumpus, Namandje N.
Hendrix, Craig W.
Cohen, Myron S.
Eshleman, Susan H.
[J]. JOURNAL OF INFECTIOUS DISEASES, 2013, 208 (10) : 1624 - 1628
[7] Effects of early versus delayed initiation of antiretroviral treatment on clinical outcomes of HIV-1 infection: results from the phase 3 HPTN 052 randomised controlled trial
Grinsztejn, Beatriz
Hosseinipour, Mina C.
Ribaudo, Heather J.
Swindells, Susan
Eron, Joseph
Chen, Ying Q.
Wang, Lei
Ou, San-San
Anderson, Maija
McCauley, Marybeth
Gamble, Theresa
Kumarasamy, Nagalingeshwaran
Hakim, James G.
Kumwenda, Johnstone
Pilotto, Jose H. S.
Godbole, Sheela V.
Chariyalertsak, Suwat
de Melo, Marineide Goncalves
Mayer, Kenneth H.
Eshleman, Susan H.
Piwowar-Manning, Estelle
Makhema, Joseph
Mills, Lisa A.
Panchia, Ravindre
Sanne, Ian
Gallant, Joel
Hoffman, Irving
Taha, Taha E.
Nielsen-Saines, Karin
Celentano, David
Essex, Max
Havlir, Diane
Cohen, Myron S.
[J]. LANCET INFECTIOUS DISEASES, 2014, 14 (04) : 281 - 290
[8] Three- vs four-drug antiretroviral regimens for the initial treatment of HIV-1 infection - A randomized controlled trial
Gulick, Roy M.
Ribaudo, Heather J.
Shikuma, Cecilia M.
Lalama, Christina
Schackman, Bruce R.
Meyer, William A., III
Acosta, Edward P.
Schouten, Jeffrey
Squires, Kathleen E.
Pilcher, Christopher D.
Murphy, Robert L.
Koletar, Susan L.
Carlson, Margrit
Reichman, Richard C.
Bastow, Barbara
Klingman, Karin L.
Kuritzkes, Daniel R.
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 296 (07): : 769 - 781
[9] Patterns of HIV-1 Drug Resistance After First-Line Antiretroviral Therapy (ART) Failure in 6 Sub-Saharan African Countries: Implications for Second-Line ART Strategies
Hamers, Raph L.
Sigaloff, Kim C. E.
Wensing, Annemarie M.
Wallis, Carole L.
Kityo, Cissy
Siwale, Margaret
Mandaliya, Kishor
Ive, Prudence
Botes, Mariette E.
Wellington, Maureen
Osibogun, Akin
Stevens, Wendy S.
de Wit, Tobias F. Rinke
Schuurman, Rob
[J]. CLINICAL INFECTIOUS DISEASES, 2012, 54 (11) : 1660 - 1669
[10] Predictors of HIV drug-resistance mutations in a large antiretroviral-naive cohort initiating triple antiretroviral therapy
Harrigan, PR
Hogg, RS
Dong, WWY
Yip, B
Wynhoven, B
Woodward, J
Brumme, CJ
Brumme, ZL
Mo, T
Alexander, CS
Montaner, JSG
[J]. JOURNAL OF INFECTIOUS DISEASES, 2005, 191 (03) : 339 - 347

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