A taurine phenolic compound (TPC) protect from AAP hepatotoxicity through involvement of Nrf2/ARE pathway

被引：0

作者：

Qiu Feng ^{[1
]}

He Xiao-Jing ^{[1
]}

机构：

[1] China Med Univ, Sheng Jing Hosp, Dept Pharm, Shenyang 110004, Peoples R China

来源：

AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH | 2010年 / 4卷 / 13期

关键词：

TPC; AAp; hepatotoxicity; Nrf2/ARE and hypothesis; KEAP1; INDUCTION; TOXICITY; STRESS;

D O I：

暂无

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Oxidative stress is a main contributor to the hepatotoxic effects of acetaminophen, the Nrf2/ARE pathway has been characterized as an important endogenous mechanism for combating oxidative stress. Taurine plays various important roles in a large number of physiological and pathological conditions in human body, such as the antioxidant, anti-inflammatory effects. It proves that phenol compound has antioxidant effect through involvement of Nrf2/ARE pathway. The taurine phenolic compound (TPC) we synthesized belongs to phenolic compounds and we have reported that a TPC protect from AAP hepatotoxicity. We thus hypothesize the protective effects of TPC in an acute chemical model of acetaminophen-induced hepatotoxicity through involvement of Nrf2/ARE pathway.

引用

页码：1460 / 1461

页数：2

共 11 条

[1] Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2 [J].

Aleksunes, Lauren M. ;

Slitt, Angela L. ;

Maher, Jonathan M. ;

Augustine, Lisa M. ;

Goedken, Michael J. ;

Chan, Jefferson Y. ;

Cherrington, Nathan J. ;

Klaassen, Curtis D. ;

Manautou, Jose E. .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2008, 226 (01) :74-83

[2] Paracetamol (acetaminophen)-induced toxicity: Molecular and biochemical mechanisms, analogues and protective approaches [J].

Bessems, JGM ;

Vermeulen, NPE .

CRITICAL REVIEWS IN TOXICOLOGY, 2001, 31 (01) :55-138

[3]

Chance B, 2005, J MOL CELL CARDIOL, V38, P879

[4] High pressure synthesis of Mg0.90Al0.08Ni0.94V0.08H1.6 [J].

Chen, J ;

Sakai, T ;

Kitamura, N ;

Takeshita, HT ;

Kuriyama, N .

METALS AND MATERIALS-KOREA, 2000, 6 (06) :605-608

[5]

Diao YP, 2009, CHINESE J STRUC CHEM, V28, P771

[6] Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants [J].

Dinkova-Kostova, AT ;

Holtzclaw, WD ;

Cole, RN ;

Itoh, K ;

Wakabayashi, N ;

Katoh, Y ;

Yamamoto, M ;

Talalay, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (18) :11908-11913

[7] Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: Role of mitochondrial oxidant stress [J].

Knight, TR ;

Kurtz, A ;

Bajt, ML ;

Hinson, JA ;

Jaeschke, H .

TOXICOLOGICAL SCIENCES, 2001, 62 (02) :212-220

[8]

KUN L, 2010, MAKINO CHINESE J ORG, V30, P128

[9]

PENG DY, 2009, CHINESE CHEM LETT, V20, P942

[10] Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin [J].

Tanigawa, Shunsuke ;

Fujii, Makoto ;

Hou, De-Xing .

FREE RADICAL BIOLOGY AND MEDICINE, 2007, 42 (11) :1690-1703

← 1 2 →