Zinc, Copper, Magnesium Levels in Polycystic Ovarian Syndrome Patients

Background: Polycystic ovarian syndrome (PCOS) is one of the most common endocrine diseases, and the status of trace elements is not clear. Aims: In the present cross-sectional study, the potential relationships between serum levels of zinc, copper, magnesium, and PCOS were explored. Materials: One hundred participants with PCOS and 100 healthy controls were studied. They were in the age group (15-35 years) with the same socio-demographic characteristics. Blood samples were drawn to estimate serum zinc, copper, and magnesium levels by autoanalyzer. Results: Serum zinc and magnesium levels were found significantly higher among the study group as compared to the control group. Serum copper levels were significantly lower in the study group. Serum copper levels were significantly correlated with age and BMI among PCOS women. Serum magnesium and zinc levels had a maximum area under the ROC curve, and the high discriminating power of serum magnesium correlated with zinc levels for PCOS. Conclusion: These results suggest that trace elements have a role in the pathogenesis of PCOS and that supplementation may help manage the disease.