Platelet function in rheumatoid arthritis: arthritic and cardiovascular implications

被引：142

作者：

Gasparyan, Armen Yuri ^{[1
]}

Stavropoulos-Kalinoglou, Antonios ^{[1
]}

Mikhailidis, Dimitri P. ^{[2
]}

Douglas, Karen M. J. ^{[1
]}

Kitas, George D. ^{[1
,3
]}

机构：

[1] Grp Hosp NHS Fdn Trust Teaching, Dept Rheumatol, Clin Res Unit, Russells Hall Hosp, Dudley DY1 2HQ, W Midlands, England

[2] UCL, Dept Clin Biochem, Vasc Prevent Clin, Royal Free Hosp,Med Sch, London, England

[3] Univ Manchester, Arthrit Res Campaign ARC Epidemiol Unit, Manchester, Lancs, England

来源：

RHEUMATOLOGY INTERNATIONAL | 2011年 / 31卷 / 02期

关键词：

Rheumatoid arthritis; Platelet function; Biomarkers; Inflammation; Cardiovascular risk; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ANTIGEN-INDUCED ARTHRITIS; SOLUBLE ADHESION MOLECULES; CONGESTIVE-HEART-FAILURE; CORONARY-ARTERY-DISEASE; P-SELECTIN EXPRESSION; TUMOR-NECROSIS-FACTOR; SYNOVIAL-FLUID; ACTIVATED PLATELETS; MYOCARDIAL-INFARCTION;

D O I：

10.1007/s00296-010-1446-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with rheumatoid arthritis (RA) are at high risk of cardiovascular events. Platelet biomarkers are involved in inflammation, atherosclerosis and thrombosis. Cardiovascular and RA-associated factors can alter the structure and function of platelets, starting from megakaryocytopoiesis. Reactive megakaryocytopoiesis increases circulating platelets count and triggers hyperactivity. Hyperactive platelets target synovial membranes with subsequent local rheumatoid inflammation. Hyperactive platelets interact with other cells, and target the vascular wall. Accumulating evidence suggests that disease modifying anti-rheumatic drugs (DMARD) decrease platelet activity.

引用

页码：153 / 164

页数：12

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