Compensation or inhibitory failure? Testing hypotheses of age-related right frontal lobe involvement in verbal memory ability using structural and diffusion MRI

被引:16
作者
Cox, Simon R. [1 ,2 ,3 ]
Bastin, Mark E. [1 ,2 ,4 ]
Ferguson, Karen J. [2 ,5 ]
Allerhand, Mike [2 ,3 ]
Royle, Natalie A. [1 ,2 ,4 ]
Maniega, Susanna Munoz [1 ,2 ,4 ]
Starr, John M. [2 ,5 ,6 ]
MacLullich, Alasdair M. J. [2 ,5 ,7 ]
Wardlaw, Joanna M. [1 ,2 ,4 ]
Deary, Ian J. [2 ,3 ]
MacPherson, Sarah E. [2 ,3 ]
机构
[1] Univ Edinburgh, Brain Res Imaging Ctr, Edinburgh EH8 9JZ, Midlothian, Scotland
[2] Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland
[3] Univ Edinburgh, Dept Psychol, Edinburgh EH8 9JZ, Midlothian, Scotland
[4] Scottish Imaging Network, Glasgow, Lanark, Scotland
[5] Univ Edinburgh, Edinburgh EH8 9JZ, Midlothian, Scotland
[6] Univ Edinburgh, Alzheimer Scotland Dementia Res Ctr, Edinburgh EH8 9JZ, Midlothian, Scotland
[7] Univ Edinburgh, Endocrinol Unit, Edinburgh EH8 9JZ, Midlothian, Scotland
基金
英国生物技术与生命科学研究理事会; 英国经济与社会研究理事会; 英国医学研究理事会;
关键词
Verbal memory; Cognitive ageing; Compensation; MRI; Frontal lobe; Corpus callosum; EPISODIC MEMORY; PREFRONTAL CORTEX; NEURAL MECHANISMS; BRAIN; RETRIEVAL; LATERALIZATION; TRACTOGRAPHY; ACTIVATION; PERFORMANCE; INTEGRITY;
D O I
10.1016/j.cortex.2014.08.001
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Functional neuroimaging studies report increased right prefrontal cortex (PFq involvement during verbal memory tasks amongst low-scoring older individuals, compared to younger controls and their higher-scoring contemporaries. Some propose that this reflects inefficient use of neural resources through failure of the left PFC to inhibit non-task-related right PFC activity, via the anterior corpus callosum (CC). For others, it indicates partial compensation that is, the right PFC cannot completely supplement the failing neural network, but contributes positively to performance. We propose that combining structural and diffusion brain MRI can be used to test predictions from these theories which have arisen from fMRI studies. We test these hypotheses in immediate and delayed verbal memory ability amongst 90 healthy older adults of mean age 73 years. Right hippocampus and left dorsolateral prefrontal cortex (DLPFC) volumes, and fractional anisotropy (FA) in the splenium made unique contributions to verbal memory ability in the whole group. There was no significant effect of anterior callosal white matter integrity on performance. Rather, segmented linear regression indicated that right DLPFC volume was a significantly stronger positive predictor of verbal memory for lower-scorers than higher-scorers, supporting a compensatory explanation for the differential involvement of the right frontal lobe in verbal memory tasks in older age. Crown Copyright (C) 2014 Published by Elsevier Ltd. This is an open access article under the CC BY license.
引用
收藏
页码:4 / 15
页数:12
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