Simulation of blood glucose regulation and anti-diabetic drug action in vivo: The Kobe model

被引：0

作者：

Fukushima, M. ^{[1
,2
]}

Sunaga, Y. ^{[2
]}

Shu, Z. ^{[3
]}

Kawahara, Y. ^{[2
]}

Seino, S. ^{[2
]}

机构：

[1] Inst Biomed Res & Innovat, Hlth Informat Res Grp, Kobe, Hyogo, Japan

[2] Kobe Univ, Grad Sch Med, Div Cellular & Mol Med, Kobe, Hyogo, Japan

[3] Insilico Technol, Kobe, Hyogo, Japan

来源：

PROCEEDINGS OF THE 8TH WORLD CONGRESS FOR MICROCIRCULATION | 2007年

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The establishment of simulation method for blood glucose regulation and actions of anti-diabetic drugs in vivo should be very helpful for providing physicians with a basis for drug selection as well as for efficient development of anti-diabetic drugs. By combination of experimental science and mathematical science, we have established the new blood glucose regulation model which is applicable to simulation in vivo of actions of sulfonylureas, the most commonly used anti-diabetic drug in the world. Based on this "KOBE MODEL", we have found different sulfonylureas have distinct effects on extrapancreatic tissues as well as pancreatic beta-cells in vivo. In addition, we have evaluated various metabolic status in rodent diabetic models. KOBE MODEL is useful for simulation of blood glucose regulation and sulfonylurea actions and for evaluation and/or prediction of the metabolic status of diabetes.

引用

页码：73 / +

页数：2

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