Intestinal multicellular organoids to study colorectal cancer

被引:21
|
作者
Idris, Musa [1 ,2 ]
Alves, Maria M. [2 ]
Hofstra, Robert M. W. [2 ]
Mahe, Maxime M. [3 ,4 ]
Melotte, Veerle [1 ,2 ]
机构
[1] Maastricht Univ Med Ctr, Dept Pathol, GROW Sch Oncol & Dev Biol, POB 616, NL-6200 MD Maastricht, Netherlands
[2] Erasmus MC, Dept Clin Genet, Rotterdam, Netherlands
[3] Cincinnati Childrens Hosp Med Ctr, Dept Pediat Gen & Thorac Surg, Cincinnati, OH USA
[4] Univ Nantes, INSERM, TENS, UMR 1235, Nantes, France
来源
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2021年 / 1876卷 / 02期
关键词
Colorectal cancer; Organoids; Tumor microenvironment; Modeling; PLURIPOTENT STEM-CELLS; HUMAN COLON; IN-VITRO; MICROENVIRONMENT; DIFFERENTIATION; EPITHELIUM; DIVERSITY; PLATFORM; DISEASE;
D O I
10.1016/j.bbcan.2021.188586
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Modeling colorectal cancer (CRC) using organoids has burgeoned in the last decade, providing enhanced in vitro models to study the development and possible treatment options for this type of cancer. In this review, we describe both normal and CRC intestinal organoid models and their utility in the cancer research field. Besides highlighting studies that develop epithelial CRC organoid models, i.e. organoids without tumor microenvironment (TME) cellular components, we emphasize on the need for TME in CRC modeling, to help reduce translational disparities in this area. Also, we discuss the utilization of CRC organoids derived from pluripotent stem cells, as well as their potential to be used in cancer research. Finally, limitations and challenges in the current CRC organoids field, are discussed.
引用
收藏
页数:9
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