Suppressive effects of androgens on the immune system

被引：391

作者：

Trigunaite, Abhishek ^{[1
]}

Dimo, Joana ^{[1
]}

Jorgensen, Trine N. ^{[1
]}

机构：

[1] Cleveland Clin Fdn, Dept Immunol, Lerner Res Inst, Cleveland, OH 44195 USA

来源：

CELLULAR IMMUNOLOGY | 2015年 / 294卷 / 02期

关键词：

Adaptive immunity; Androgen; Androgen receptor; Autoimmunity; Cancer; Innate immunity; Sex-bias; Testosterone; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; PLASMACYTOID DENDRITIC CELLS; PERIPHERAL LYMPHOID ORGANS; PROSTATE-CANCER; SEX-DIFFERENCES; T-CELLS; TESTOSTERONE TREATMENT; GENDER-DIFFERENCES; ALPHA PRODUCTION; B-LYMPHOPOIESIS;

D O I：

10.1016/j.cellimm.2015.02.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sex-based disparities in immune responses are well known phenomena. The two most important factors accounting for the sex-bias in immunity are genetics and sex hormones. Effects of female sex hormones, estrogen and progesterone are well established, however the role of testosterone is not completely understood. Evidence from unrelated studies points to an immunosuppressive role of testosterone on different components of the immune system, but the underlying molecular mechanisms remains unknown. In this review we evaluate the effect of testosterone on key cellular components of innate and adaptive immunity. Specifically, we highlight the importance of testosterone in down-regulating the systemic immune response by cell type specific effects in the context of immunological disorders. Further studies are required to elucidate the molecular mechanisms of testosterone-induced immunosuppression, leading the way to the identification of novel therapeutic targets for immune disorders. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：87 / 94

页数：8

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