Wacker-Type Oxidation Using an Iron Catalyst and Ambient Air: Application to Late-Stage Oxidation of Complex Molecules

被引：82

作者：

Liu, Binbin ^{[1
]}

Jin, Fengli ^{[1
]}

Wang, Tianjiao ^{[1
]}

Yuan, Xiaorong ^{[1
]}

Han, Wei ^{[1
]}

机构：

[1] Nanjing Normal Univ, Sch Chem & Mat Sci, Jiangsu Key Lab Biofunct Mat, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Wenyuan Rd 1, Nanjing 210023, Jiangsu, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 41期

关键词：

alkenes; iron; ketones; oxidation; radicals; ANTI-MARKOVNIKOV OXIDATION; TERMINAL OLEFINS; METHYL KETONES; SELECTIVE OXIDATION; HYDROGEN-PEROXIDE; ORGANIC-SYNTHESIS; INTERNAL OLEFINS; AEROBIC OXIDATION; SOLE OXIDANT; ALKENES;

D O I：

10.1002/anie.201707006

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A practical and general iron-catalyzed Wacker-type oxidation of olefins to ketones is presented, and it uses ambient air as the sole oxidant. The mild oxidation conditions enable exceptional functional-group tolerance, which has not been demonstrated for any other Wacker-type reaction to date. The inexpensive and nontoxic reagents [iron(II) chloride, polymethylhydrosiloxane, and air] can, therefore, also be employed to oxidize complex natural-product-derived and polyfunctionalized molecules.

引用

页码：12712 / 12717

页数：6