UVB-protective effects of isoflavone extracts from soybean cake in human keratinocytes

被引：16

作者：

Chiang, Han-Sun

Wu, Wen-Bin

Fang, Jia-You

Chen, Bing-Huei

Kao, Tsai-Hua

Chen, Ying-Ting

Huang, Chieh-Chen

Hung, Chi-Feng ^{[1
]}

机构：

[1] Fu Jen Catholic Univ, Sch Med, Taipei, Taiwan

[2] Chang Gung Univ, Grad Inst Nat Prod, Pharmaceut Lab, Tao Yuan, Taiwan

[3] Fu Jen Catholic Univ, Dept Nutr & Food Sci, Taipei, Taiwan

[4] Shin Kong Wu Ho Su Mem Hosp, Dept Dermatol, Taipei, Taiwan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2007年 / 8卷 / 07期

关键词：

isoflavone; keratinocyte; UVB;

D O I：

10.3390/i8070651

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been shown by chromatography that aglycone, glucoside, acetylglucoside and malonylglucoside isoflavone extracts prepared from soybean cake showed better antioxidant activities than isoflavone standards. Consequently, the aim of this study was to evaluate the protective effects of these isoflavone extracts against ultraviolet B (UVB)induced keratinocyte damage. Our results demonstrated that these soybean cake isoflavone extracts could inhibit UVB-induced keratinocyte death. Moreover, they could inhibit UVB-induced intracellular release of hydrogen peroxide (H2O2) Furthermore, these isoflavone extracts differentially inhibited UVB-induced MAPK phosphorylation. The ERK1/2 and p38 phosphorylation was not inhibited by all tested isoflavone extracts, whereas JNK phosphorylation was inhibited by group I to group III isoflavone extracts. Since these isoflavone extracts are relative stable and easily obtained than the isoflavone standards, we suggest that soybean cake may be a useful potential source for developing effective skin care agents in against photoaging.

引用

页码：651 / 661

页数：11

共 29 条

[1] Pomegranate fruit extract modulates UV-B-mediated phosphorylation of mitogen-activated protein kinases and activation of nuclear factor kappa B in normal human epidermal keratinocytes [J].