Hydrolytic cleavage of DNA by a ruthenium(II) polypyridyl complex

被引：66
|
作者：
Deshpande, Megha S. [1 ]
Kumbhar, Anupa A. [1 ]
Kumbhar, Avinash S. [1 ]
机构：
[1] Univ Pune, Dept Chem, Pune 4110079, Maharashtra, India
来源：
INORGANIC CHEMISTRY | 2007年 / 46卷 / 14期
关键词：
D O I：
10.1021/ic070331d
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The complex [Ru(bpy)(2)(BPG)]Cl-2 containing hydrogen-bond donor (N-H atoms) and acceptor (O atoms) groups mediates hydrolytic cleavage of plasmid pBR322 DNA in an enzyme-like manner. The kinetic aspects of DNA cleavage under pseudo- and true-Michaelis-Menten conditions are detailed.
引用
收藏
页码：5450 / 5452
页数：3
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