First diastereoselective asymmetric carbometallation of chiral vinyl metals.

被引：18

作者：

Brasseur, D

Rezaei, H

Fuxa, A

Alexakis, A

Mangeney, P

Marek, I

Normant, JF ^{[1
]}

机构：

[1] Technion Israel Inst Technol, Dept Chem, IL-32000 Haifa, Israel

[2] Univ Paris 06, CNRS, Lab Chim Organoelements, F-75252 Paris 05, France

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 27期

关键词：

amines; asymmetric induction; chelation; zinc reagents;

D O I：

10.1016/S0040-4039(98)00942-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Addition of substituted allylzinc reagents to chiral (Z) metallated allyl amines (or aminal) bearing a chiral aromatic moiety is face selective, and delivers beta-methylated amines with good diastereomeric excess. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：4821 / 4824

页数：4

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