Transcriptional Architecture of the Primate Neocortex

被引：176

作者：

Bernard, Amy ^{[1
]}

Lubbers, Laura S. ^{[2
]}

Tanis, Keith Q. ^{[3
]}

Luo, Rui ^{[6
]}

Podtelezhnikov, Alexei A. ^{[3
]}

Finney, Eva M. ^{[3
]}

McWhorter, Mollie M. E. ^{[4
]}

Serikawa, Kyle ^{[4
]}

Lemon, Tracy ^{[1
]}

Morgan, Rebecca ^{[1
]}

Copeland, Catherine ^{[1
]}

Smith, Kimberly ^{[1
]}

Cullen, Vivian ^{[4
]}

Davis-Turak, Jeremy ^{[5
]}

Lee, Chang-Kyu ^{[1
]}

Sunkin, Susan M. ^{[1
]}

Loboda, Andrey P. ^{[3
]}

Levine, David M. ^{[4
]}

Stone, David J. ^{[3
]}

Hawrylycz, Michael J. ^{[1
]}

Roberts, Christopher J. ^{[3
]}

Jones, Allan R. ^{[1
]}

Geschwind, Daniel H. ^{[5
,6
]}

Lein, Ed S. ^{[1
]}

机构：

[1] Allen Inst Brain Sci, Seattle, WA 98103 USA

[2] Merck Res Labs, Dept Neurosci, West Point, PA 19486 USA

[3] Merck Res Labs, Dept Informat & Anal, West Point, PA 19486 USA

[4] Rosetta Inpharmat, Seattle, WA 98109 USA

[5] Univ Calif Los Angeles, David Geffen Sch Med, Program Neurogenet, Dept Neurol, Los Angeles, CA 90095 USA

[6] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA

来源：

NEURON | 2012年 / 73卷 / 06期

关键词：

MONKEY VISUAL-CORTEX; CEREBRAL-CORTEX; GENE-EXPRESSION; HUMAN BRAIN; NEURONAL CLASSES; SMALL-WORLD; ORGANIZATION; PATTERNS; RNA; SPECIFICATION;

D O I：

10.1016/j.neuron.2012.03.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Genome-wide transcriptional profiling was used to characterize the molecular underpinnings of neocortical organization in rhesus macaque, including cortical areal specialization and laminar cell-type diversity. Microarray analysis of individual cortical layers across sensorimotor and association cortices identified robust and specific molecular signatures for individual cortical layers and areas, prominently involving genes associated with specialized neuronal function. Overall, transcriptome-based relationships were related to spatial proximity, being strongest between neighboring cortical areas and between proximal layers. Primary visual cortex OM displayed the most distinctive gene expression compared to other cortical regions in rhesus and human, both in the specialized layer 4 as well as other layers. Laminar patterns were more similar between macaque and human compared to mouse, as was the unique V1 profile that was not observed in mouse. These data provide a unique resource detailing neocortical transcription patterns in a nonhuman primate with great similarity in gene expression to human.

引用

页码：1083 / 1099

页数：17

共 50 条

[1] Genome-wide analyses of human perisylvian cerebral cortical patterning [J].